Xrcc5

Gene Symbol	Xrcc5
Entrez Gene	22596
Alt Symbol	AI314015, Ku80, Ku86
Species	Mouse
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 5
Other Description	ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit|CTC85|CTCBF|DNA repair protein XRCC5|Ku p80|X-ray repair cross-complementing protein 5|ku autoantigen protein p86 homolog|nuclear factor IV
Swissprots	Q3TN82 Q3TE46 Q9R169 P27641 Q8C4N6 Q80UT1 Q3TJT0 Q8K1K7
Accessions	EDL00282 P27641 AF166486 AAD49720 AK010416 BAB26920 AK081633 BAC38276 AK084263 AK089944 AK165470 BAE38207 AK167312 BAE39415 AK168913 BAE40726 AK169838 BAE41402 AK177313 AK182445 AK197342 AK199633 AK200491 AK214786 BC029218 AAH29218 BC051660 AAH51660 CJ220465 X66323 CAA46999 XM_006495892 XP_006495955 XM_006495893 XP_006495956 XM_006495894 XP_006495957 NM_009533 NP_033559
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing
Subcellular Location	Nucleus. Nucleus, nucleolus {ECO:0000250}. Chromosome.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

XRCC5 antibody - 10R-11223 from Fitzgerald Prices $295.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone M82182

Ku80 antibody - 70R-31327 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

XRCC5 antibody - 70R-30841 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Ku70/80 antibody - 70R-31262 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

XRCC5 Antibody - abx116695 from Abbexa Host Rabbit Clonality Polyclonal

XRCC5 / Ku80 / Ku86 antibody - PAB12580 from Acris Antibodies Prices $430.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

XRCC5 / Ku80 / Ku86 antibody - PAB12581 from Acris Antibodies Prices $430.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

p80 Ku - MBS604314 from MyBioSource Prices $510.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone 0.T.107

Anti-XRCC5 (aa 323-338) polyclonal antibody - DPAB-DC985 from Creative Diagnostics Host Rabbit Clonality Polyclonal

Anti-XRCC5 (aa 419-440) polyclonal antibody - DPAB-DC986 from Creative Diagnostics Host Rabbit Clonality Polyclonal

XRCC5 Antibody - CSB-PA026233GA01HU from Cusabio Host Rabbit

Polyclonal Antibody to X-Ray Repair Cross Complementing 5 (XRCC5) - PAD013Mu01 from Cloud-clone Host Rabbit Clonality Polyclonal

Polyclonal Antibody to X-Ray Repair Cross Complementing 5 (XRCC5) - PAD013Mu02 from Cloud-clone Host Rabbit Clonality Polyclonal

Ku-86 (B-4) - sc-515736 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

XRCC5, Monoclonal Antibody - MBS5307731 from MyBioSource Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone M82182

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