| Gene Symbol | Xrcc5 |
|---|---|
| Entrez Gene | 22596 |
| Alt Symbol | AI314015, Ku80, Ku86 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | X-ray repair complementing defective repair in Chinese hamster cells 5 |
| Other Description | ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit|CTC85|CTCBF|DNA repair protein XRCC5|Ku p80|X-ray repair cross-complementing protein 5|ku autoantigen protein p86 homolog|nuclear factor IV |
| Swissprots | Q3TN82 Q3TE46 Q9R169 P27641 Q8C4N6 Q80UT1 Q3TJT0 Q8K1K7 |
| Accessions | EDL00282 P27641 AF166486 AAD49720 AK010416 BAB26920 AK081633 BAC38276 AK084263 AK089944 AK165470 BAE38207 AK167312 BAE39415 AK168913 BAE40726 AK169838 BAE41402 AK177313 AK182445 AK197342 AK199633 AK200491 AK214786 BC029218 AAH29218 BC051660 AAH51660 CJ220465 X66323 CAA46999 XM_006495892 XP_006495955 XM_006495893 XP_006495956 XM_006495894 XP_006495957 NM_009533 NP_033559 |
| Function | Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing |
| Subcellular Location | Nucleus. Nucleus, nucleolus {ECO:0000250}. Chromosome. |
| Top Pathways | Non-homologous end-joining |