| Gene Symbol |
ESRRA
|
| Entrez Gene |
2101
|
| Alt Symbol |
ERR1, ERRa, ERRalpha, ESRL1, NR3B1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
estrogen-related receptor alpha
|
| Other Description |
ERR-alpha|estrogen receptor-like 1|estrogen-related nuclear receptor alpha|nuclear receptor subfamily 3 group B member 1|steroid hormone receptor ERR1
|
| Swissprots |
Q14514 P11474
|
| Accessions |
ABF47104 EAW74245 EAW74246 EAW74250 P11474 AB362579 BAF81543 BC007915 AAH07915 BC011528 AAH11528 BC033701 AAH33701 BC063795 AAH63795 BC073956 AAH73956 BC092470 AAH92470 BC093720 AAH93720 BC093722 AAH93722 DB478332 EU446471 ABZ92000 HQ692867 ADZ17378 L38487 AAB17015 X51416 CAA35778 NM_001282450 NP_001269379 NM_001282451 NP_001269380 NM_004451 NP_004442
|
| Function |
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. {ECO:0000269|PubMed:12522104, ECO:0000269|PubMed:16150865, ECO:0000269|PubMed:17676930, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:9271417}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:18063693}.
|
