GALNT6
| Gene Symbol | GALNT6 |
|---|---|
| Entrez Gene | 11226 |
| Alt Symbol | GALNAC-T6, GalNAcT6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polypeptide N-acetylgalactosaminyltransferase 6 |
| Other Description | GalNAc transferase 6|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6|UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)|polypeptide GalNAc transferase 6|pp-GaNTase 6|protein-UDP acetylgalactosaminyltransferase 6 |
| Swissprots | Q8NCL4 Q9UIV5 Q9H6G2 Q8IYH4 |
| Accessions | CAM83953 EAW58190 Q8NCL4 AB265820 BAJ10977 AK025961 BAB15297 AK074658 BAC11118 AK092496 BAG52560 AK296852 BAG59418 BC035822 AAH35822 BC114505 AAI14506 BC114949 DB001644 DQ891224 ABM82150 DQ894407 ABM85333 Y08565 CAA69876 XM_005268607 XP_005268664 XM_006719214 XP_006719277 XM_011537814 XP_011536116 XM_011537815 XP_011536117 XM_011537816 XP_011536118 XM_011537817 XP_011536119 XM_011537818 XP_011536120 XM_011537819 XP_011536121 XM_011537820 XP_011536122 XM_011537821 XP_011536123 XM_011537822 XP_011536124 NM_007210 NP_009141 |
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in placenta and trachea. Weakly expressed in brain and pancreas. Expressed in fibroblast. Weakly or not expressed in lung, liver, muscle, kidney, spleen, thymus, prostate, testis, ovary, intestine, colon, leukocyte, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland and bone marrow. {ECO:0000269|PubMed:10464263}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T6 CRISPR/Cas9 KO Plasmid (h) - sc-409126 from Santa Cruz Biotechnology
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GalNAc-T6 HDR Plasmid (h) - sc-409126-HDR from Santa Cruz Biotechnology
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GalNAc-T6 Double Nickase Plasmid (h) - sc-409126-NIC from Santa Cruz Biotechnology
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GalNAc-T6 Double Nickase Plasmid (h2) - sc-409126-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T6 CRISPR Activation Plasmid (h) - sc-409126-ACT from Santa Cruz Biotechnology
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GalNAc-T6 CRISPR Activation Plasmid (h2) - sc-409126-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T6 Lentiviral Activation Particles (h) - sc-409126-LAC from Santa Cruz Biotechnology
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GalNAc-T6 Lentiviral Activation Particles (h2) - sc-409126-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T6 siRNA (h) - sc-75100 from Santa Cruz Biotechnology
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GalNAc-T6 shRNA Plasmid (h) - sc-75100-SH from Santa Cruz Biotechnology
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GalNAc-T6 shRNA (h) Lentiviral Particles - sc-75100-V from Santa Cruz Biotechnology
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GALNT6 RNAi - H00011226-R01V from Novus Biologicals
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GALNT6 RNAi - H00011226-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9111 from Sigma-Aldrich
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GALNT6 siRNA (Human) - CRH7693 from Cohesion Biosciences
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GALNT6 - MBS8233455 from MyBioSource
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shRNA set against Human GALNT6 (NM_007210.3) - SHH299077 from Creative biogene
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shRNA set against Human GALNT6(NM_007210.3) - SHH076421 from Creative biogene
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GALNT6 shRNA Plasmid (Human) - CHH7693 from Cohesion Biosciences
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GALNT6 miRNA 3'UTR clone - MiUTR1H-03941 from Creative biogene
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