| Gene Symbol | SGIP1 |
|---|---|
| Entrez Gene | 84251 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | SH3-domain GRB2-like (endophilin) interacting protein 1 |
| Other Description | SH3-containing GRB2-like protein 3-interacting protein 1|endophilin-3-interacting protein |
| Swissprots | A6NL81 Q5VYE3 Q68D76 Q9BQI5 Q5VYE2 Q4LE32 Q6MZY6 Q8IWC2 A6NLD1 Q5VYE4 |
| Accessions | EAX06521 EAX06522 EAX06523 Q9BQI5 AB210039 BAE06121 AK090697 BAG52213 AK125044 BAC86031 AK298970 BAH12914 AK299941 BAH13177 AL136561 CAB66496 AM392887 CAL37765 AW205180 BC040516 AAH40516 BX640813 CAE45891 CR749541 CAH18344 DA491011 DA724991 DA801276 EU831934 ACE87375 EU832029 ACE86691 XM_005271264 XP_005271321 XM_005271265 XP_005271322 XM_005271266 XP_005271323 XM_005271268 XP_005271325 XM_005271269 XP_005271326 XM_005271270 XP_005271327 XM_006710961 XP_006711024 XM_006710962 XP_006711025 XM_006710963 XP_006711026 XM_006710964 XP_006711027 XM_006710965 XP_006711028 XM_006710966 XP_006711029 XM_006710967 XP_006711030 XM_006710968 XP_006711031 XM_006710969 XP_006711032 XM_006710971 XP_006711034 XM_006710972 XP_006711035 XM_006710973 XP_006711036 XM_006710974 XP_006711037 XM_011542286 XP_011540588 XM_011542287 XP_011540589 XM_011542288 XP_011540590 XM_011542289 XP_011540591 XM_011542290 XP_011540592 XM_011542291 XP_011540593 XM_011542292 XP_011540594 XM_011542293 XP_011540595 XM_011542294 XP_011540596 XM_011542295 XP_011540597 NM_001308203 NP_001295132 NM_032291 NP_115667 |
| Function | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane, clathrin-coated pit {ECO:0000305|PubMed:20946875}; Peripheral membrane protein {ECO:0000305|PubMed:20946875}; Cytoplasmic side {ECO:0000305|PubMed:20946875}. |
| Tissue Specificity | Specifically expressed in brain. {ECO:0000269|PubMed:15919751}. |
SGIP1 CRISPR/Cas9 KO Plasmid (h) - sc-408395 from Santa Cruz Biotechnology
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SGIP1 HDR Plasmid (h) - sc-408395-HDR from Santa Cruz Biotechnology
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SGIP1 Double Nickase Plasmid (h) - sc-408395-NIC from Santa Cruz Biotechnology
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SGIP1 Double Nickase Plasmid (h2) - sc-408395-NIC-2 from Santa Cruz Biotechnology
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SGIP1 CRISPR Activation Plasmid (h) - sc-408395-ACT from Santa Cruz Biotechnology
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SGIP1 CRISPR Activation Plasmid (h2) - sc-408395-ACT-2 from Santa Cruz Biotechnology
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SGIP1 Lentiviral Activation Particles (h) - sc-408395-LAC from Santa Cruz Biotechnology
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SGIP1 Lentiviral Activation Particles (h2) - sc-408395-LAC-2 from Santa Cruz Biotechnology
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SGIP1 siRNA (h) - sc-78847 from Santa Cruz Biotechnology
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SGIP1 shRNA Plasmid (h) - sc-78847-SH from Santa Cruz Biotechnology
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SGIP1 shRNA (h) Lentiviral Particles - sc-78847-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19224 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19224 from Sigma-Aldrich
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SGIP1 siRNA (Human) - CRJ3379 from Cohesion Biosciences
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SGIP1 - MBS828092 from MyBioSource
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shRNA set against Human SGIP1 (NM_032291.2) - SHH406236 from Creative biogene
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shRNA set against Human SGIP1(NM_032291.2) - SHR221538 from Creative biogene
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Human SGIP1 siRNA - orb273880 from Biorbyt
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SGIP1 shRNA Plasmid (Human) - CHJ3379 from Cohesion Biosciences
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SGIP1 miRNA 3'UTR clone - MiUTR1H-09349 from Creative biogene
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