Gene Symbol | FBP2 |
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Entrez Gene | 100008853 |
Alt Symbol | - |
Species | Rabbit |
Gene Type | protein-coding |
Description | fructose-1,6-bisphosphatase 2 |
Other Description | D-fructose-1,6-bisphosphate 1-phosphohydrolase 2|FBPase 2|fructose-1,6-bisphosphatase isozyme 2|muscle FBPase |
Swissprots | Q9N0J6 |
Accessions | CBF86937 CBG16979 CBV02386 CBV30425 Q9N0J6 AJ272520 CAB76202 GBCI01123328 NM_001082128 NP_001075597 |
Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269|PubMed:12860378, ECO:0000269|PubMed:15757649, ECO:0000269|PubMed:17350621, ECO:0000269|PubMed:18214967}. |
Subcellular Location | Cell junction {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:15757649}. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}. |
Top Pathways | Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Carbon metabolism |
Recombinant Rabbit Fructose-1,6-bisphosphatase isozyme 2(FBP2) - CSB-YP889014RB CSB-EP889014RB CSB-BP889014RB CSB-MP889014RB from Cusabio
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Fructose-1,6-bisphosphatase isozyme 2 (FBP2), Recombinant Protein - MBS1418603 from MyBioSource
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