| Gene Symbol |
srd5a3
|
| Entrez Gene |
560717
|
| Alt Symbol |
S5AR 3, fj40g12, si:ch211-278f21.3, srd5a2l, wu:fj40g12
|
| Species |
Zebrafish
|
| Gene Type |
protein-coding
|
| Description |
steroid 5 alpha-reductase 3
|
| Other Description |
3-oxo-5-alpha-steroid 4-dehydrogenase 3|SR type 3|polyprenol reductase|probable polyprenol reductase|steroid 5-alpha-reductase 3
|
| Swissprots |
A4FVI8 Q5RIU9
|
| Accessions |
Q5RIU9 AW233719 AW280458 BC097226 BC117626 BC133964 AAI33965 CB353112 NM_001044939 NP_001038404
|
| Function |
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
Steroid hormone biosynthesis
|