| Gene Symbol |
unc45b
|
| Entrez Gene |
266640
|
| Alt Symbol |
Unc-45B, cb393, unc45r, wu:fa05a03, wu:fa10f03, wu:fb37f02, wu:fb96f06, wu:fc10f04
|
| Species |
Zebrafish
|
| Gene Type |
protein-coding
|
| Description |
unc-45 homolog B (C. elegans)
|
| Other Description |
fb37f02|protein unc-45 homolog B|unc-45B
|
| Swissprots |
Q6DGE9 Q8UVX6
|
| Accessions |
Q6DGE9 AF330001 AAL57031 BC076400 AAH76400 EB780723 NM_153673 NP_705959
|
| Function |
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. {ECO:0000250|UniProtKB:Q8CGY6, ECO:0000269|PubMed:17189627, ECO:0000269|PubMed:17586488, ECO:0000269|PubMed:20440001, ECO:0000269|PubMed:20849610}.
|
| Subcellular Location |
Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}.
|
| Tissue Specificity |
Expressed in striated muscle tissue including somites, heart and craniofacial muscle. Detected in mesoderm adjacent to the dorsal midline during the late gastrula stages and in somitic mesoderm during development of trunk skeletal muscle. Also expressed in cranial skeletal muscle and in cardiac and smooth muscle. Detected in somitic muscle and heart primordium of 24 hour embryos. At later stages, expressed in muscles of pectoral fins, jaw, branchial arches and eye. {ECO:0000269|PubMed:12203738, ECO:0000269|PubMed:17189627}.
|