| Gene Symbol | Lep |
|---|---|
| Entrez Gene | 25608 |
| Alt Symbol | OB, obese |
| Species | Rat |
| Gene Type | protein-coding |
| Description | leptin |
| Other Description | obesity factor |
| Swissprots | P50596 |
| Accessions | AAM33120 EDM15202 EDM15203 P50596 D45862 BAA08296 D49653 BAA08529 S78586 AAB34657 U48849 AAC52514 XM_008762762 XP_008760984 NM_013076 NP_037208 |
| Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of Lep may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
LEP siRNA (Rat) - CRR0811 from Cohesion Biosciences
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shRNA set against Rat LEP (NM_013076.3) - SHH329615 from Creative biogene
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Rat LEP siRNA - orb295660 from Biorbyt
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LEP shRNA Plasmid (Rat) - CHR0811 from Cohesion Biosciences
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