| Gene Symbol | EFNA2 |
|---|---|
| Entrez Gene | 1943 |
| Alt Symbol | ELF-1, EPLG6, HEK7-L, LERK-6, LERK6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ephrin-A2 |
| Other Description | HEK7 ligand|eph-related receptor tyrosine kinase ligand 6 |
| Swissprots | O76020 O43921 |
| Accessions | AAC04896 AAC39577 AAG16277 EAW69517 O43921 AJ007292 CAA07435 BC146278 AAI46279 BC148727 AAI48728 NM_001405 NP_001396 |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. |
| Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |