Gene Symbol | EFNA2 |
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Entrez Gene | 1943 |
Alt Symbol | ELF-1, EPLG6, HEK7-L, LERK-6, LERK6 |
Species | Human |
Gene Type | protein-coding |
Description | ephrin-A2 |
Other Description | HEK7 ligand|eph-related receptor tyrosine kinase ligand 6 |
Swissprots | O76020 O43921 |
Accessions | AAC04896 AAC39577 AAG16277 EAW69517 O43921 AJ007292 CAA07435 BC146278 AAI46279 BC148727 AAI48728 NM_001405 NP_001396 |
Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. |
Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |
ephrin-A2 (H-175) - sc-33163 from Santa Cruz Biotechnology
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ephrin-A2 (L-20) - sc-912 from Santa Cruz Biotechnology
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Anti-Ephrin A2 antibody - ab199694 from Abcam
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Anti-Ephrin A2 antibody - ab65041 from Abcam
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Anti-Ephrin A2 antibody - ab72661 from Abcam
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Anti-Ephrin A2 antibody - ab116035 from Abcam
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Anti-Ephrin A2 antibody [2C6] - ab117941 from Abcam
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Anti-Ephrin A2 antibody [3E3] - ab123877 from Abcam
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Anti-EFNA2 / Ephrin A2 Antibody (Cleaved) - LS-C342188 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (clone 2C6) - LS-C115438 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (aa76-125) - LS-C145503 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (aa139-188) - LS-C121075 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (aa1-50) - LS-C118688 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (clone 3E1) - LS-C115430 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (clone 1C9) - LS-C115413 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (clone 2D6) - LS-C115436 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (clone 2E6) - LS-C115431 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (clone 4C3) - LS-C115437 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (clone 3E3) - LS-C172352 from LifeSpan Bioscience
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Anti-EFNA2 / Ephrin A2 Antibody (Asn33) - LS-C176702 from LifeSpan Bioscience
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Ephrin-A2 Antibody (3E3) - NBP2-02810 from Novus Biologicals
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Ephrin-A2 Antibody - NB100-92287 from Novus Biologicals
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Ephrin-A2 Antibody - H00001943-B01 from Novus Biologicals
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Ephrin-A2 Antibody - H00001943-B01P from Novus Biologicals
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Anti-EFNA2 antibody produced in mouse - SAB1408964 from Sigma-Aldrich
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