| Gene Symbol |
CPEB1
|
| Entrez Gene |
64506
|
| Alt Symbol |
CPE-BP1, CPEB, CPEB-1, h-CPEB, hCPEB-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytoplasmic polyadenylation element binding protein 1
|
| Other Description |
CPE-binding protein 1|cytoplasmic polyadenylation element-binding protein 1
|
| Swissprots |
Q8IV41 Q9BZB7 Q86W46 B7Z6C6 Q9BZB8 Q9H8V5
|
| Accessions |
EAW62448 EAW62449 EAW62450 EAW62451 EAW62452 Q9BZB8 AF329402 AAK01239 AF329403 AAK01240 AK023265 BAB14496 AK294280 BAH11723 AK300105 BAH13212 AK301728 BAG63194 AL832156 BC035348 AAH35348 BC050629 AAH50629 BM715948 BX649159 DA340952 DA705313 HQ448361 ADQ32841 HY007452 HY191346 NM_001079533 NP_001073001 NM_001079534 NP_001073002 NM_001079535 NP_001073003 NM_001288819 NP_001275748 NM_001288820 NP_001275749 NM_030594 NP_085097
|
| Function |
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU- 3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. {ECO:0000250, ECO:0000269|PubMed:15731006, ECO:0000269|Pu
|
| Subcellular Location |
Cytoplasm, P-body. Cytoplasmic granule. Cell junction, synapse. Membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines. {ECO:0000269|PubMed:11223249, ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895}.
|
| Top Pathways |
Progesterone-mediated oocyte maturation, Oocyte meiosis, Dorso-ventral axis formation
|