| Gene Symbol |
Cbl
|
| Entrez Gene |
12402
|
| Alt Symbol |
4732447J05Rik, Cbl-2, c-Cbl, cbl
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
Casitas B-lineage lymphoma
|
| Other Description |
E3 ubiquitin-protein ligase CBL|casitas B-lineage lymphoma proto-oncogene|proto-oncogene c-CBL|signal transduction protein CBL
|
| Swissprots |
Q3U527 Q8CEA1 P22682
|
| Accessions |
AAX90623 EDL25568 EDL25569 P22682 AK029826 AK039331 AK152275 AK153915 BAE32253 AK154208 AK163907 AK171171 BC125285 AAI25286 DQ551619 DQ552121 DQ558455 DQ561007 DQ563690 DQ565003 DQ566411 DQ685220 DQ686041 DQ687164 DQ690538 DQ695987 DQ714235 DQ716370 DQ722607 DQ722615 DQ723886 DQ725309 DQ727228 EF442242 ABR68919 X57111 CAA40394 XM_006509963 XP_006510026 NM_007619 NP_031645
|
| Function |
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be
|
| Subcellular Location |
Cytoplasm. Cell membrane {ECO:0000250}. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane. {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, ErbB signaling pathway, Insulin signaling pathway, Chronic myeloid leukemia, Endocytosis
|