| Gene Symbol | CD79B |
|---|---|
| Entrez Gene | 974 |
| Alt Symbol | AGM6, B29, IGB |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD79b molecule, immunoglobulin-associated beta |
| Other Description | B-cell antigen receptor complex-associated protein beta chain|B-cell-specific glycoprotein B29|CD79b antigen (immunoglobulin-associated beta)|Ig-beta|immunoglobulin-associated B29 protein |
| Swissprots | P40259 Q53FS2 Q9BU06 |
| Accessions | AAA72424 AAA98831 CCF76965 CCF76966 CCF76967 CDM22282 EAW94227 EAW94228 EAW94229 EAW94230 EAW94231 EAW94232 P40259 AK222954 BAD96674 AK223210 BAD96930 AK313583 BAG36353 AX775815 CAE11607 AX775817 CAE11608 BC002975 AAH02975 BC030210 AAH30210 BC032651 AAH32651 M80461 AAA58387 M89957 AAA64459 S52229 AAB24822 S79249 AAC60654 X83539 CAA58522 XM_005257858 XP_005257915 NM_000626 NP_000617 NM_001039933 NP_001035022 NM_021602 NP_067613 |
| Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269|PubMed:12097390, ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}. |
| Tissue Specificity | B-cells. |
| Top Pathways | B cell receptor signaling pathway |
CD79B CRISPR/Cas9 KO Plasmid (h) - sc-401760 from Santa Cruz Biotechnology
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CD79B HDR Plasmid (h) - sc-401760-HDR from Santa Cruz Biotechnology
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CD79B Double Nickase Plasmid (h) - sc-401760-NIC from Santa Cruz Biotechnology
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CD79B Double Nickase Plasmid (h2) - sc-401760-NIC-2 from Santa Cruz Biotechnology
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CD79B CRISPR Activation Plasmid (h) - sc-401760-ACT from Santa Cruz Biotechnology
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CD79B CRISPR Activation Plasmid (h2) - sc-401760-ACT-2 from Santa Cruz Biotechnology
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CD79B Lentiviral Activation Particles (h) - sc-401760-LAC from Santa Cruz Biotechnology
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CD79B Lentiviral Activation Particles (h2) - sc-401760-LAC-2 from Santa Cruz Biotechnology
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CD79B siRNA (h) - sc-35027 from Santa Cruz Biotechnology
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CD79B shRNA Plasmid (h) - sc-35027-SH from Santa Cruz Biotechnology
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CD79B shRNA (h) Lentiviral Particles - sc-35027-V from Santa Cruz Biotechnology
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CD79B RNAi - H00000974-R03 from Novus Biologicals
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CD79B RNAi - H00000974-R04 from Novus Biologicals
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MISSION® esiRNA - EHU097211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5751 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04079 from Sigma-Aldrich
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CD79B siRNA (Human) - CRH0695 from Cohesion Biosciences
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CD79B - MBS8232367 from MyBioSource
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CD79B CRISPR/Cas9 KO Plasmid (h2) - sc-401760-KO-2 from Santa Cruz Biotechnology
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CD79B HDR Plasmid (h2) - sc-401760-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CD79B (NM_000626.2) - SHH259365 from Creative biogene
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shRNA set against Human CD79B(NM_000626.2) - SHG159301 from Creative biogene
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shRNA set against Human CD79B(NM_001039933.1) - SHG159337 from Creative biogene
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shRNA set against Human CD79B(NM_021602.2) - SHG159355 from Creative biogene
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