ATP1A1
| Gene Symbol | ATP1A1 |
|---|---|
| Entrez Gene | 476 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Na+/K+ transporting, alpha 1 polypeptide |
| Other Description | Na(+)/K(+) ATPase alpha-1 subunit|Na+, K+ ATPase alpha subunit|Na+/K+ ATPase 1|Na, K-ATPase, alpha-A catalytic polypeptide|Na,K-ATPase alpha-1 subunit|Na,K-ATPase catalytic subunit alpha-A protein|sodium pump 1|sodium pump subunit alpha-1|sodium-potassium ATPase catalytic subunit alpha-1|sodium-potassium-ATPase, alpha 1 polypeptide|sodium/potassium-transporting ATPase subunit alpha-1 |
| Swissprots | Q6LDM4 Q16689 Q9UJ21 B2RBR6 B7Z2T5 P05023 Q9UCN1 F5H3A1 B7Z3U6 Q9UJ20 |
| Accessions | AAA35573 AAA35574 AAA51801 AAA92713 EAW56644 EAW56645 EAW56646 EAW56647 EAW56648 P05023 AK293689 BAH11571 AK295095 BAH11971 AK296362 BAH12332 AK296384 BAH12337 AK308418 AK314777 BAG37313 AL531892 AY642124 AY946013 AAX55908 BC001330 AAH01330 BC003077 AAH03077 BC050359 AAH50359 BF795089 DC335233 DQ891882 ABM82808 EU176649 ABW03450 J03007 AAA51803 M16793 AAD56251 M16794 AAD56252 U16798 AAC50131 XM_006710655 XP_006710718 NM_000701 NP_000692 NM_001160233 NP_001153705 NM_001160234 NP_001153706 NM_001001586 |
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Top Pathways | Salivary secretion, Cardiac muscle contraction, cAMP signaling pathway, Aldosterone-regulated sodium reabsorption, Thyroid hormone synthesis |
Na + /K + -ATPase α siRNA (h) - sc-43956 from Santa Cruz Biotechnology
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Na + /K + -ATPase α shRNA Plasmid (h) - sc-43956-SH from Santa Cruz Biotechnology
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Na + /K + -ATPase α shRNA (h) Lentiviral Particles - sc-43956-V from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 siRNA (h) - sc-36010 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 shRNA Plasmid (h) - sc-36010-SH from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 shRNA (h) Lentiviral Particles - sc-36010-V from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 CRISPR/Cas9 KO Plasmid (h) - sc-400239 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 HDR Plasmid (h) - sc-400239-HDR from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 Double Nickase Plasmid (h) - sc-400239-NIC from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 Double Nickase Plasmid (h2) - sc-400239-NIC-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 CRISPR Activation Plasmid (h) - sc-400239-ACT from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 CRISPR Activation Plasmid (h2) - sc-400239-ACT-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 Lentiviral Activation Particles (h) - sc-400239-LAC from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 Lentiviral Activation Particles (h2) - sc-400239-LAC-2 from Santa Cruz Biotechnology
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Sodium Potassium ATPase Alpha 1 RNAi - H00000476-R04 from Novus Biologicals
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Sodium Potassium ATPase Alpha 1 RNAi - H00000476-R03 from Novus Biologicals
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MISSION® esiRNA - EHU080631 from Sigma-Aldrich
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MISSION® esiRNA - EHU103451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1786 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1786 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02619 from Sigma-Aldrich
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ATP1A1 siRNA (Human) - CRH0332 from Cohesion Biosciences
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ATP1A1 - MBS8218072 from MyBioSource
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shRNA set against Human ATP1A1 (NM_000701.7) - SHH242506 from Creative biogene
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Human ATP1A1 siRNA - orb260834 from Biorbyt
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