| Gene Symbol |
Nptn
|
| Entrez Gene |
20320
|
| Alt Symbol |
AW554172, SDR-1, Sdfr1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
neuroplastin
|
| Other Description |
stromal cell derived factor receptor 1
|
| Swissprots |
Q8C6H8 Q3U519 Q8C637 P97300
|
| Accessions |
EDL25955 EDL25956 EDL25957 P97300 AA790392 AK075610 BAC35855 AK076624 BAC36420 AK153930 BAE32261 BC039191 BY266099 D50463 BAA09054 XM_006510882 XP_006510945 XM_006510883 XP_006510946 XM_006510884 XP_006510947 XM_006510885 XP_006510948 XM_006510886 XP_006510949 NM_001293673 NP_001280602 NM_009145 NP_033171
|
| Function |
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Enriched at postsynaptic density. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are widely expressed with variable levels in brain. Isoform 1 is expressed in cerebellum and midbrain. Isoform 1 and isoform 2 are expressed in cerebral cortex, hipoccampus and striatum. Isoform 2 is more abundant in the cerebral cortex than isoform 1. {ECO:0000269|PubMed:8938438, ECO:0000269|Ref.5}.
|