| Gene Symbol | DDB2 |
|---|---|
| Entrez Gene | 1643 |
| Alt Symbol | DDBB, UV-DDB2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | damage-specific DNA binding protein 2, 48kDa |
| Other Description | DDB p48 subunit|DNA damage-binding protein 2|UV-DDB 2|UV-damaged DNA-binding protein 2|damage-specific DNA-binding protein 2|xeroderma pigmentosum group E protein |
| Swissprots | Q76E56 Q76E55 Q76E54 Q92466 Q76E57 B2R875 |
| Accessions | AAO25655 EAW67952 EAW67953 EAW67954 EAW67955 EAW67956 EAW67957 EAW67958 EAW67959 Q92466 AA278953 AB107037 BAD12557 AB107038 BAD12558 AB107039 BAD12559 AB107040 BAD12560 AK091640 AK313262 BAG36072 BC000093 AAH00093 BC050455 BT007139 AAP35803 DB053816 DQ890719 ABM81645 HQ447914 ADQ32398 U18300 AAB07897 XR_242780 NM_000107 NP_000098 NM_001300734 NP_001287663 |
| Function | Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4- ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA r |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10777490, ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16713579, ECO:0000269|PubMed:17635991, ECO:0000269|PubMed:18593899}. Note=Accumulates at sites of DNA damage following UV irradiation. |
| Tissue Specificity | Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed. {ECO:0000269|PubMed:14751237}. |
| Top Pathways | p53 signaling pathway, Ubiquitin mediated proteolysis, Nucleotide excision repair |