DDB2

Gene Symbol	DDB2
Entrez Gene	1643
Alt Symbol	DDBB, UV-DDB2
Species	Human
Gene Type	protein-coding
Description	damage-specific DNA binding protein 2, 48kDa
Other Description	DDB p48 subunit|DNA damage-binding protein 2|UV-DDB 2|UV-damaged DNA-binding protein 2|damage-specific DNA-binding protein 2|xeroderma pigmentosum group E protein
Swissprots	Q76E56 Q76E55 Q76E54 Q92466 Q76E57 B2R875
Accessions	AAO25655 EAW67952 EAW67953 EAW67954 EAW67955 EAW67956 EAW67957 EAW67958 EAW67959 Q92466 AA278953 AB107037 BAD12557 AB107038 BAD12558 AB107039 BAD12559 AB107040 BAD12560 AK091640 AK313262 BAG36072 BC000093 AAH00093 BC050455 BT007139 AAP35803 DB053816 DQ890719 ABM81645 HQ447914 ADQ32398 U18300 AAB07897 XR_242780 NM_000107 NP_000098 NM_001300734 NP_001287663
Function	Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4- ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA r
Subcellular Location	Nucleus {ECO:0000269|PubMed:10777490, ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16713579, ECO:0000269|PubMed:17635991, ECO:0000269|PubMed:18593899}. Note=Accumulates at sites of DNA damage following UV irradiation.
Tissue Specificity	Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed. {ECO:0000269|PubMed:14751237}.
Top Pathways	p53 signaling pathway, Ubiquitin mediated proteolysis, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DDB-2 (D4C4) Rabbit mAb - 5416 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D4C4

DDB2 (H-127) - sc-25368 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DDB2 (I-20) - sc-28406 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DDB2 (S-16) - sc-16295 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DDB2 (2246C4a) - sc-81246 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-DDB2 antibody - ab77765 from Abcam Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DDB2 antibody - ab171895 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DDB2 antibody [2246C4a] - ab51017 from Abcam Prices $400.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2246C4a

Anti-DDB2 antibody [EPR9811] - ab181136 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9811

Anti-DDB2 Antibody - LS-C331725 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DDB2 Antibody (clone 1F11) - LS-C197030 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1F11

Anti-DDB2 Antibody - LS-C310101 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DDB2 Antibody (clone 2246C4a) - LS-C184404 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2246C4a

Anti-DDB2 Antibody (aa351-400) - LS-C135730 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DDB2 Antibody - LS-C192754 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DDB2 Antibody (aa166-383) - LS-C314463 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DDB2 Antibody (clone 2246C4a) - LS-C342450 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2246C4a

Anti-DDB2 Antibody (C-Terminus) - LS-C18970 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDB2 Antibody - LS-C64562 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-DDB2 Antibody (C-Terminus) - LS-C128545 from LifeSpan Bioscience Prices $680.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDB2 Antibody - LS-C155129 from LifeSpan Bioscience Prices $245.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDB2 Antibody (clone 11C1023) - LS-C183822 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone 11C1023

XPE/DDB2 Antibody - AF3297 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

XPE/DDB2 Antibody - NBP2-38854 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

XPE/DDB2 Antibody - NBP1-68879 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

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