| Gene Symbol | IFNT2 |
|---|---|
| Entrez Gene | 317698 |
| Alt Symbol | IFN-tau-c2, IFNT, IFNT1, TP-1 |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | interferon tau |
| Other Description | IFN-tau-1|IFN-tau-2|IFN-tau1|IFN-tau2|antiluteolysin|interferon alpha II|interferon tau-1|interferon tau-2|interferon, trophoblast|interferon-tau1e|interferon-tau3e|trophoblast antiluteolytic protein|trophoblast protein 1|trophoblast protein-1|trophoblast type I interferon|trophoblastin |
| Swissprots | Q95NE2 Q28127 P15696 Q28126 Q28191 Q28128 P15694 P56830 |
| Accessions | AAA62711 AAA62712 AAB67325 AAG14169 AAX98268 CAA46506 P15696 P56830 AF196320 AAF08671 AF196321 AAF08672 AF196322 AAF08673 AF196323 AAF08674 EU828775 ACF58054 EU828776 ACF58055 EU828777 ACF58056 EU828778 ACF58057 M31556 AAA50457 M31557 AAA50458 M31558 AAA50459 NM_001015511 NP_001015511 |
| Function | Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally induc |
| Subcellular Location | Secreted. Note=Secreted into the uterine lumen. |
| Tissue Specificity | Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm. |
Interferon tau-1, IFNT1, Bovine, ELISA Kit - E2106b from ARP American Research Products
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Interferon Tau (IFNt), ELISA Kit - MBS2025596 from MyBioSource
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Interferon tau-1, ELISA Kit - MBS288312 from MyBioSource
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Cow Interferon Tau ELISA Kit - abx258204 from Abbexa
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Bovine IFNT2 ELISA Kit (Sandwich ELISA) - LS-F25328 from LifeSpan Bioscience
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Bovine Interferon Tau (IFNt) ELISA Kit - EKU09093 from Biomatik
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Bovine IFNT1 ELISA Kit - E086364 from Biobool
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Bovine IFNT2 ELISA Kit - E086366 from Biobool
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Bovine Interferon Tau (IFNt) ELISA Kit - AE58169BO from ARP American Research Products
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Interferon Tau (IFNt), ELISA Kit - MBS2703815 from MyBioSource
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