| Gene Symbol |
TONSL
|
| Entrez Gene |
505102
|
| Alt Symbol |
NFKBIL2
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
tonsoku-like, DNA repair protein
|
| Other Description |
I-kappa-B-related protein|NF-kappa-B inhibitor-like protein 2|ikappaBR|inhibitor of kappa B-related protein|nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2|tonsoku-like protein
|
| Swissprots |
Q0P5G1
|
| Accessions |
CAD58807 DAA22851 Q0P5G1 BC120084 AAI20085 NM_001075188 NP_001068656
|
| Function |
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks (By similarity). {ECO:0000250}.
|