| Gene Symbol | TONSL |
|---|---|
| Entrez Gene | 505102 |
| Alt Symbol | NFKBIL2 |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | tonsoku-like, DNA repair protein |
| Other Description | I-kappa-B-related protein|NF-kappa-B inhibitor-like protein 2|ikappaBR|inhibitor of kappa B-related protein|nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2|tonsoku-like protein |
| Swissprots | Q0P5G1 |
| Accessions | CAD58807 DAA22851 Q0P5G1 BC120084 AAI20085 NM_001075188 NP_001068656 |
| Function | Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks (By similarity). {ECO:0000250}. |