| Gene Symbol |
KLHL7
|
| Entrez Gene |
55975
|
| Alt Symbol |
KLHL6, SBBI26
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kelch-like family member 7
|
| Other Description |
kelch-like 6|kelch-like 7|kelch-like protein 7|kelch/BTB
|
| Swissprots |
A4D144 Q9UDQ9 Q96MV2 G5E9G3 B7Z5I9 Q9BQF8 Q8IXQ5 Q7Z765
|
| Accessions |
AAO21916 EAL24261 EAW93770 EAW93771 EAW93772 EAW93773 EAW93774 Q8IXQ5 AA432360 AF111113 AAF27196 AK056390 BAB71175 AK290479 BAF83168 AK296219 BAH12285 AK297369 BAH12563 AK297421 BAH12577 AK297595 BAH12623 AK299006 BAH12925 AK302995 BAH13872 AL136597 CAB66532 AL834193 AY028802 AAK29099 BC009555 AAH09555 BC039585 AAH39585 BG704835 DC370850 EF560731 ABQ59041 EU831631 ACE87231 EU831716 ACE86550 EU831829 ACE86588 EU832811 ACE87822 GQ129238 ACT64372 XM_006715753 XP_006715816 XM_006715754 XP_006715817 XM_006715755 XP_006715818 XM_006715756 XP_006715819 XM_006715757 XP_006715820 NM_001031710 NP_001026880 NM_001172428 NP_001165899 NM_018846 NP_061334 NR_033328 NR_033329
|
| Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. {ECO:0000269|PubMed:21828050}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16918702}.
|
| Tissue Specificity |
Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis. {ECO:0000269|PubMed:16918702}.
|
![Western Blot: KLHL7 Overexpression Lysate (Adult Normal) [NBL1-12342] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KLHL7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6569_KLHL7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12342-img0002.jpg)