Gene Symbol | EIF4H |
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Entrez Gene | 7458 |
Alt Symbol | WBSCR1, WSCR1, eIF-4H |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 4H |
Other Description | Williams-Beuren syndrome chromosome region 1 |
Swissprots | D3DXF8 Q15056 D3DXF6 A8K3R1 |
Accessions | AAC04859 AAF75557 AAS07403 AAS07439 AAS07440 EAW69615 EAW69616 EAW69617 EAW69618 EAW69619 Q15056 AK290676 BAF83365 AK297651 BAG60018 AK314749 BC010021 AAH10021 BC021214 AAH21214 BC023534 BC066928 AAH66928 D26068 BAA05063 DQ891924 ABM82850 DQ895111 ABM86037 DQ895112 ABM86038 XM_011516556 XP_011514858 XM_011516557 XP_011514859 NM_022170 NP_071496 NM_031992 NP_114381 |
Function | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250}. |
Tissue Specificity | The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney. {ECO:0000269|PubMed:11003705, ECO:0000269|PubMed:8812460}. |
eIF4H CRISPR/Cas9 KO Plasmid (h) - sc-411056 from Santa Cruz Biotechnology
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eIF4H HDR Plasmid (h) - sc-411056-HDR from Santa Cruz Biotechnology
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eIF4H Double Nickase Plasmid (h) - sc-411056-NIC from Santa Cruz Biotechnology
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eIF4H Double Nickase Plasmid (h2) - sc-411056-NIC-2 from Santa Cruz Biotechnology
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eIF4H CRISPR Activation Plasmid (h) - sc-411056-ACT from Santa Cruz Biotechnology
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eIF4H CRISPR Activation Plasmid (h2) - sc-411056-ACT-2 from Santa Cruz Biotechnology
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eIF4H Lentiviral Activation Particles (h) - sc-411056-LAC from Santa Cruz Biotechnology
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eIF4H Lentiviral Activation Particles (h2) - sc-411056-LAC-2 from Santa Cruz Biotechnology
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eIF4H siRNA (h) - sc-89585 from Santa Cruz Biotechnology
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eIF4H shRNA Plasmid (h) - sc-89585-SH from Santa Cruz Biotechnology
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eIF4H shRNA (h) Lentiviral Particles - sc-89585-V from Santa Cruz Biotechnology
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eIF4H RNAi - H00007458-R01 from Novus Biologicals
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MISSION® esiRNA - EHU089401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7786 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7786 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10653 from Sigma-Aldrich
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EIF4H siRNA (Human) - CRH5102 from Cohesion Biosciences
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eIF4H RNAi - H00007458-R02 from Novus Biologicals
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EIF4H - MBS8218794 from MyBioSource
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shRNA set against Human EIF4H (NM_022170.1) - SHH284765 from Creative biogene
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shRNA set against Human EIF4H(NM_031992.1) - SHH030233 from Creative biogene
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shRNA set against Human EIF4H(NM_022170.1) - SHH030251 from Creative biogene
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Human EIF4H siRNA - orb265604 from Biorbyt
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EIF4H shRNA Plasmid (Human) - CHH5102 from Cohesion Biosciences
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EIF4H miRNA 3'UTR clone - MiUTR1H-03179 from Creative biogene
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