NTRK2
| Gene Symbol | NTRK2 |
|---|---|
| Entrez Gene | 4915 |
| Alt Symbol | GP145-TrkB, TRKB, trk-B |
| Species | Human |
| Gene Type | protein-coding |
| Description | neurotrophic tyrosine kinase, receptor, type 2 |
| Other Description | BDNF-tropomyosine receptor kinase B|BDNF/NT-3 growth factors receptor|tropomyosin-related kinase B|tyrosine kinase receptor B |
| Swissprots | Q8WXJ7 Q16620 Q59GJ1 B4DFV9 Q8WXJ5 B1ANZ4 Q8WXJ6 Q16675 |
| Accessions | AAL67968 EAW62687 EAW62688 EAW62689 EAW62690 EAW62691 EAW62692 EAW62693 Q16620 AB209118 BAD92355 AF086101 AF400441 AAK92490 AF410898 AAL67964 AF410899 AAL67965 AF410900 AAL67966 AF410901 AAL67967 AF508964 AAM77876 AJ420458 AK092267 AK123824 AK289904 BAF82593 AK294285 BAG57570 AL533181 AL713745 AL833196 AW235842 BC031309 BC031835 AAH31835 BC075804 BE148667 BE466753 BX649001 DA283111 DA449367 HY311899 KC855566 AGR50957 S76473 AAB33109 S76474 AAB33110 U12140 AAC51371 X75958 CAA53571 XM_005252001 XP_005252058 XM_005252003 XP_005252060 XM_005252004 XP_005252061 XM_005252006 XP_005252063 XM_005252007 XP_005252064 XM_011518718 XP_011517020 XM_011518719 XP_011517021 XM_011518720 XP_011517022 NM_001007097 NP_001007098 NM_001018064 NP_001018074 NM_001018065 NP_001018075 NM_001018066 NP_001018076 NM_001291937 NP_001278866 NM_006180 NP_006171 |
| Function | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Internalized to endosomes upon ligand-binding. {ECO:0000250}. |
| Tissue Specificity | Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain. {ECO:0000269|PubMed:11798182, ECO:0000269|PubMed:7936202}. |
| Top Pathways | MAPK signaling pathway, Neurotrophin signaling pathway, Alcoholism |
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