| Gene Symbol |
DLD
|
| Entrez Gene |
1738
|
| Alt Symbol |
DLDD, DLDH, E3, GCSL, LAD, PHE3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dihydrolipoamide dehydrogenase
|
| Other Description |
E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex|diaphorase|dihydrolipoyl dehydrogenase, mitochondrial|glycine cleavage system L protein|glycine cleavage system protein L|lipoamide dehydrogenase|lipoamide reductase|lipoyl dehydrogenase
|
| Swissprots |
B4DHG0 P09622 Q14131 Q59EV8 B2R5X0 Q14167 B4DT69 Q8WTS4
|
| Accessions |
AAA35759 AAB01381 EAL24389 EAW83421 EAW83422 P09622 AB209703 BAD92940 AK225289 AK225301 AK294146 BAG57472 AK295080 BAG58122 AK297508 BAG59921 AK300077 BAG61881 AK310220 AK312346 BAG35267 BC018648 AAH18648 BC018696 AAH18696 BI562331 DC354209 HQ447584 ADQ32070 J03490 AAA59527 J03620 AAA35764 NM_000108 NP_000099 NM_001289750 NP_001276679 NM_001289751 NP_001276680 NM_001289752 NP_001276681
|
| Function |
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
|
| Subcellular Location |
Mitochondrion matrix.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Glycine, serine and threonine metabolism, Pyruvate metabolism, Carbon metabolism
|
