Gene Symbol | SDHD |
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Entrez Gene | 6392 |
Alt Symbol | CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS |
Species | Human |
Gene Type | protein-coding |
Description | succinate dehydrogenase complex, subunit D, integral membrane protein |
Other Description | succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial|succinate-ubiquinone oxidoreductase cytochrome b small subunit|succinate-ubiquinone reductase membrane anchor subunit |
Swissprots | Q6IRW2 A6ND90 E9PIC0 Q53XW5 E9PIG3 O14521 E9PQI9 B3KQQ8 |
Accessions | BAA81889 EAW67181 EAW67182 EAW67183 O14521 AA374642 AB006202 BAA22054 AI753083 AK075360 BAG52120 BC005263 AAH05263 BC009574 AAH09574 BC012603 AAH12603 BC015188 AAH15188 BC015992 AAH15992 BC022350 AAH22350 BC070307 AAH70307 BC071755 AAH71755 BC071756 AAH71756 BE567994 BF211358 BG492859 BQ000657 BQ932668 BT007238 AAP35902 BX419391 CD105572 CR456932 CAG33213 DQ892701 ABM83627 DQ896292 ABM87291 NM_001276503 NP_001263432 NM_001276504 NP_001263433 NM_001276506 NP_001263435 NM_003002 NP_002993 NR_077060 |
Function | Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000250}. |
Subcellular Location | Mitochondrion inner membrane; Multi-pass membrane protein. |
Top Pathways | Citrate cycle (TCA cycle), Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |
SDHD CRISPR/Cas9 KO Plasmid (h) - sc-403276 from Santa Cruz Biotechnology
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SDHD HDR Plasmid (h) - sc-403276-HDR from Santa Cruz Biotechnology
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SDHD Double Nickase Plasmid (h) - sc-403276-NIC from Santa Cruz Biotechnology
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SDHD Double Nickase Plasmid (h2) - sc-403276-NIC-2 from Santa Cruz Biotechnology
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SDHD CRISPR Activation Plasmid (h) - sc-403276-ACT from Santa Cruz Biotechnology
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SDHD CRISPR Activation Plasmid (h2) - sc-403276-ACT-2 from Santa Cruz Biotechnology
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SDHD Lentiviral Activation Particles (h) - sc-403276-LAC from Santa Cruz Biotechnology
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SDHD Lentiviral Activation Particles (h2) - sc-403276-LAC-2 from Santa Cruz Biotechnology
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SDHD siRNA (h) - sc-61512 from Santa Cruz Biotechnology
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SDHD shRNA Plasmid (h) - sc-61512-SH from Santa Cruz Biotechnology
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SDHD shRNA (h) Lentiviral Particles - sc-61512-V from Santa Cruz Biotechnology
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SDHD RNAi - H00006392-R01 from Novus Biologicals
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MISSION® esiRNA - EHU103791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19005 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19005 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07206 from Sigma-Aldrich
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SDHD siRNA (Human) - CRH4317 from Cohesion Biosciences
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SDHD - MBS8227597 from MyBioSource
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SDHD CRISPR/Cas9 KO Plasmid (h2) - sc-403276-KO-2 from Santa Cruz Biotechnology
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SDHD HDR Plasmid (h2) - sc-403276-HDR-2 from Santa Cruz Biotechnology
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SDHD shRNA Plasmid (Human) - CHH4317 from Cohesion Biosciences
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SDHD miRNA 3'UTR clone - MiUTR3H-05232 from Creative biogene
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