Gene Symbol | DUSP6 |
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Entrez Gene | 1848 |
Alt Symbol | HH19, MKP3, PYST1 |
Species | Human |
Gene Type | protein-coding |
Description | dual specificity phosphatase 6 |
Other Description | MAP kinase phosphatase 3|dual specificity protein phosphatase 6|dual specificity protein phosphatase PYST1|mitogen-activated protein kinase phosphatase 3|serine/threonine specific protein phosphatase |
Swissprots | Q9BSH6 Q53Y75 O75109 Q16828 |
Accessions | BAA31968 CBX53900 EAW97422 EAW97423 EAW97424 Q16828 AB013382 BAA34369 AB013602 BAA31969 AB189400 BAD38886 AB451265 BAG70079 AB451393 BAG70207 AK091753 AK222882 BAD96602 AU135449 BC003143 AAH03143 BC003562 AAH03562 BC005047 AAH05047 BC037236 AAH37236 BF087219 BT006895 AAP35541 DA105027 DQ892490 ABM83416 DQ895701 ABM86627 X93920 CAA63813 NM_001946 NP_001937 NM_022652 NP_073143 |
Function | Inactivates MAP kinases. Has a specificity for the ERK family. |
Subcellular Location | Cytoplasm. |
Top Pathways | MAPK signaling pathway, Transcriptional misregulation in cancer |
MKP-3 CRISPR/Cas9 KO Plasmid (h) - sc-400850 from Santa Cruz Biotechnology
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MKP-3 HDR Plasmid (h) - sc-400850-HDR from Santa Cruz Biotechnology
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MKP-3 Double Nickase Plasmid (h) - sc-400850-NIC from Santa Cruz Biotechnology
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MKP-3 Double Nickase Plasmid (h2) - sc-400850-NIC-2 from Santa Cruz Biotechnology
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MKP-3 CRISPR Activation Plasmid (h) - sc-400850-ACT from Santa Cruz Biotechnology
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MKP-3 CRISPR Activation Plasmid (h2) - sc-400850-ACT-2 from Santa Cruz Biotechnology
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MKP-3 Lentiviral Activation Particles (h) - sc-400850-LAC from Santa Cruz Biotechnology
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MKP-3 Lentiviral Activation Particles (h2) - sc-400850-LAC-2 from Santa Cruz Biotechnology
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MKP-3 siRNA (h) - sc-39000 from Santa Cruz Biotechnology
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MKP-3 shRNA Plasmid (h) - sc-39000-SH from Santa Cruz Biotechnology
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MKP-3 shRNA (h) Lentiviral Particles - sc-39000-V from Santa Cruz Biotechnology
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MKP-3/DUSP6 RNAi - H00001848-R01V from Novus Biologicals
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MISSION® esiRNA - EHU081071 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0144 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0142 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0143 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2035 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2035 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08513 from Sigma-Aldrich
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DUSP6 siRNA (Human) - CRH1296 from Cohesion Biosciences
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MKP-3/DUSP6 RNAi - H00001848-R01 from Novus Biologicals
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MKP-3/DUSP6 RNAi - H00001848-R02 from Novus Biologicals
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DUSP6 - MBS8231547 from MyBioSource
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MKP-3 CRISPR/Cas9 KO Plasmid (h2) - sc-400850-KO-2 from Santa Cruz Biotechnology
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MKP-3 HDR Plasmid (h2) - sc-400850-HDR-2 from Santa Cruz Biotechnology
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