Gene Symbol | GJA1 |
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Entrez Gene | 2697 |
Alt Symbol | AVSD3, CMDR, CX43, GJAL, HLHS1, HSS, ODDD |
Species | Human |
Gene Type | protein-coding |
Description | gap junction protein, alpha 1, 43kDa |
Other Description | connexin 43|connexin-43|gap junction 43 kDa heart protein|gap junction alpha-1 protein |
Swissprots | P17302 Q9Y5I8 Q6FHU1 B2R5U9 |
Accessions | AAD37802 EAW48178 P17302 AK223289 BAD97009 AK294670 BAG57837 AK295460 BAG58393 AK297402 BAG59841 AK297761 BAG60109 AK297764 BAG60112 AK309377 AK309490 AK312324 BAG35246 AW664595 BC026329 AAH26329 BP226987 CR541660 CAG46461 DQ893649 ABM84575 DQ895611 ABM86537 M65188 AAA52131 X52947 CAA37122 NM_000165 NP_000156 |
Function | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:22411987}; Multi-pass membrane protein {ECO:0000269|PubMed:22411987}. Cell junction, gap junction {ECO:0000269|PubMed:22411987}. |
Tissue Specificity | Expressed in the heart and fetal cochlea. {ECO:0000269|PubMed:11741837}. |
Top Pathways | Gap junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
Human GJA1 / CX43 / Connexin 43 ELISA Kit (Sandwich ELISA) - LS-F5235 from LifeSpan Bioscience
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Mouse GJA1 / CX43 / Connexin 43 ELISA Kit (Sandwich ELISA) - LS-F6165 from LifeSpan Bioscience
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Rat GJA1 / CX43 / Connexin 43 ELISA Kit (Sandwich ELISA) - LS-F6166 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-GJA1 / CX43 / Connexin 43 (Ser367) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1478 from LifeSpan Bioscience
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Mouse/Human/Rat GJA1 / CX43 / Connexin 43 ELISA Kit (Cell-Based ELISA) - LS-F1905 from LifeSpan Bioscience
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Human Connexin 43 ELISA Kit - abx151149 from Abbexa
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Connexin 43 (CX43), Human, ELISA Kit - SEA277Hu from ARP American Research Products
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Connexin 43, Human, ELISA Kit - E01C0559 from ARP American Research Products
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Connexin 43, CX43, Human, ELISA Kit - E-EL-H1681 from ARP American Research Products
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Gap junction alpha-1 protein (GJA1), Human, ELISA Kit - E01G0425 from ARP American Research Products
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Gap junction alpha-1 protein, GJA1, Human, ELISA Kit - E2241h from ARP American Research Products
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Connexin 43, CX43, Mouse, ELISA Kit - E-EL-M0345 from ARP American Research Products
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Connexin 43, CX43, Rat, ELISA Kit - E-EL-R0264 from ARP American Research Products
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Connexin 43, CX43, Rabbit, ELISA Kit - E-EL-RB1401 from ARP American Research Products
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Connexin 43, CX43, Chicken, ELISA Kit - E-EL-Ch0840 from ARP American Research Products
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Connexin 43, CX43, Porcine, ELISA Kit - E-EL-P1376 from ARP American Research Products
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Connexin 43, CX43, Sheep, ELISA Kit - E-EL-S0480 from ARP American Research Products
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Connexin 43, CX43, Guinea Pig, ELISA Kit - E-EL-GP1240 from ARP American Research Products
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Connexin 43, CX43, Monkey, ELISA Kit - E-EL-MK0356 from ARP American Research Products
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Human CX43 ELISA Kit - HC0566 from NeoScientific
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Anserine CX43 ELISA Kit - AC0566 from NeoScientific
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Gap junction Alpha 1 protein (GJA1), ELISA Kit - MBS7242265 from MyBioSource
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Gap junction Alpha 1 protein (GJA1), ELISA Kit - MBS7221328 from MyBioSource
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Gap junction alpha-1 protein, ELISA Kit - MBS281328 from MyBioSource
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Gap junction alpha-1 protein (GJA1), ELISA Kit - MBS7201539 from MyBioSource
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