| Gene Symbol |
TRERF1
|
| Entrez Gene |
55809
|
| Alt Symbol |
BCAR2, HSA277276, RAPA, TREP132, TReP-132, dJ139D8.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcriptional regulating factor 1
|
| Other Description |
breast cancer anti-estrogen resistance 2|rapa-1|rapa-2|transcriptional regulating protein 132|transcriptional-regulating factor 1|transcriptional-regulating protein 132|zinc finger protein rapa|zinc finger transcription factor TReP-132
|
| Swissprots |
Q9NQ72 Q7Z6T2 Q7Z6T3 Q96PN7 Q05GC6 Q9NUN9 Q9NQ73
|
| Accessions |
CAK32328 CCQ43803 EAX04088 EAX04089 EAX04090 EAX04091 EAX04092 EAX04093 Q96PN7 AF111801 AAL39003 AF297872 AAL01653 AJ277275 CAB88206 AJ277276 CAB88207 AK002096 BAA92082 AK127493 BAG54514 AK308473 AM404182 CAL49296 AM404183 CAL49297 AM404259 CAL49295 BC047920 BC156203 AAI56204 XM_006715145 XP_006715208 XM_006715147 XP_006715210 XM_006715148 XP_006715211 XM_011514741 XP_011513043 XM_011514742 XP_011513044 XM_011514743 XP_011513045 XM_011514744 XP_011513046 XM_011514745 XP_011513047 XM_011514746 XP_011513048 XM_011514747 XP_011513049 XM_011514748 XP_011513050 XM_011514749 XP_011513051 XM_011514750 XP_011513052 XM_011514751 XP_011513053 XM_011514752 XP_011513054 NM_001297573 NP_001284502 NM_001297574 NP_001284503 NM_033502 NP_277037 NM_018415 NM_033501
|
| Function |
Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:11349124}.
|
| Tissue Specificity |
Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells. {ECO:0000269|PubMed:11349124}.
|
![Western Blot: TRERF1 Overexpression Lysate (Adult Normal) [NBP2-05876] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TRERF1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/17557_TRERF1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05876-img0001.jpg)