| Gene Symbol |
HSPA1A
|
| Entrez Gene |
282254
|
| Alt Symbol |
HSP70-2, HSPA1B, HSPA2
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
heat shock 70kDa protein 1A
|
| Other Description |
70 kda heat shock protein-2|HSP70.2|chaperone|heat shock 70 kD protein 2|heat shock 70 kDa protein 1B|heat shock 70 kDa protein 2|heat shock 70kDa protein 1B|heat-shock 70-kilodalton protein 1B
|
| Swissprots |
Q28122 Q27965 Q3ZBV7
|
| Accessions |
AAA03451 AAN78093 DAA16344 Q27965 BC103083 AAI03084 EU038069 ABS80938 NM_203322 NP_976067
|
| Function |
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. {ECO:0000250|UniProtKB:P08107}.
|
| Tissue Specificity |
Testis-specific.
|
| Top Pathways |
Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles
|