| Gene Symbol | CD36 |
|---|---|
| Entrez Gene | 948 |
| Alt Symbol | BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD36 molecule (thrombospondin receptor) |
| Other Description | CD36 antigen (collagen type I receptor, thrombospondin receptor)|GPIIIB|PAS IV|PAS-4 protein|cluster determinant 36|fatty acid translocase|glycoprotein IIIb|leukocyte differentiation antigen CD36|platelet glycoprotein 4|platelet glycoprotein IV|scavenger receptor class B, member 3 |
| Swissprots | Q9BQC2 D9IX67 Q9BZN5 D9IX66 D9IX68 Q9BZM8 Q16093 Q9BZN4 D9IX69 Q8TCV7 P16671 Q9BPZ8 Q9BZN3 Q13966 |
| Accessions | AAB46390 AAG60624 AAG60625 AAG60626 AAG60627 AAG60628 AAG60629 AAG60630 AAG60631 AAG60632 AAG60633 AAG60634 AAG60635 AAG60636 AAG60637 AAG60638 AAG60639 AAM14636 AHA62517 AIY28314 AIY28315 CAA80504 CAA83662 CBH19823 EAL24191 EAW76996 EAW76997 EAW76998 EAW76999 EAW77000 EAW77001 EAW77002 EAW77003 EAW77004 EAW77005 P16671 AA846141 AK057690 AK096858 BAG53380 AK129899 AK300101 BAH13209 AK312920 BAG35765 AL596924 BC008406 AAH08406 BP258762 BP259746 CR749465 DA566475 DA857400 DC338512 DQ893062 ABM83988 DQ896314 ABM87313 HM217020 ADI80540 HM217021 ADI80541 HM217022 ADI80542 HM217023 ADI80543 HM217024 ADI80544 HM217025 ADI80545 HM217026 ADI80546 L06850 AAA16068 M24795 AAA35534 M98398 AAA58412 M98399 AAA58413 S60719 AAD14932 S60720 AAD14933 S67044 AAB28992 S67532 AAD13993 XM_005250713 XP_005250770 XM_005250714 XP_005250771 XM_005250715 XP_005250772 XM_011516707 XP_011515009 NM_000072 NP_000063 NM_001001547 NP_001001547 NM_001001548 NP_001001548 NM_001127443 NP_001120915 NM_001127444 NP_001120916 NM_001289908 NP_001276837 NM_001289909 NP_001276838 NM_001289911 NP_001276840 NR_110501 |
| Function | Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. {ECO:0000269|PubMed:10890433, ECO:0000269|PubMed:12506336, ECO:0000269|PubMed:20037584}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000269|PubMed:20037584}. |
| Top Pathways | ECM-receptor interaction, Hematopoietic cell lineage, Adipocytokine signaling pathway, PPAR signaling pathway, Phagosome |