| Gene Symbol | CACNG7 |
|---|---|
| Entrez Gene | 59284 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, gamma subunit 7 |
| Other Description | TARP gamma-7|neuronal voltage-gated calcium channel gamma-7 subunit|transmembrane AMPAR regulatory protein gamma-7|voltage-dependent calcium channel gamma-7 subunit |
| Swissprots | P62955 Q52LL8 Q9BXT1 Q8VBX3 Q8WXS6 |
| Accessions | CAC36507 EAW72162 EAW72163 EAW72164 EAW72165 EAW72166 P62955 AF288387 AAK20030 AF361353 AAL50048 AF458897 AAM00594 AL537399 BC069332 AAH69332 BC093869 AAH93869 BC113503 AAI13504 HQ258374 ADR83128 XM_005259124 XP_005259181 NM_031896 NP_114102 |
| Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:21172611}. |
| Subcellular Location | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11170751}. |
| Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |