Gene Symbol | CXCL11 |
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Entrez Gene | 6373 |
Alt Symbol | H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-X-C motif) ligand 11 |
Other Description | C-X-C motif chemokine 11|beta-R1|interferon gamma-inducible protein 9|interferon-inducible T-cell alpha chemoattractant|small inducible cytokine B11|small inducible cytokine subfamily B (Cys-X-Cys), member 11|small inducible cytokine subfamily B (Cys-X-Cys), member 9B|small-inducible cytokine B11 |
Swissprots | Q53YA3 O14625 Q92840 |
Accessions | AAD10206 AAD38327 CAB51859 CAB69205 EAX05774 O14625 AF002985 AAC51845 AF030514 AAC39775 AF352781 AAK52900 AL703031 BC005292 AAH05292 BC012532 AAH12532 BC110986 AAI10987 BP289021 BT006787 AAP35433 DQ895703 ABM86629 EU176355 ABW03806 U59286 AAB17374 U66096 AAD38867 Y15220 CAA75510 NM_001302123 NP_001289052 NM_005409 NP_005400 |
Function | Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. |
Subcellular Location | Secreted. |
Tissue Specificity | High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders. |
Top Pathways | Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Chemokine signaling pathway |
I-TAC CRISPR/Cas9 KO Plasmid (h) - sc-417548 from Santa Cruz Biotechnology
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I-TAC HDR Plasmid (h) - sc-417548-HDR from Santa Cruz Biotechnology
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I-TAC Double Nickase Plasmid (h) - sc-417548-NIC from Santa Cruz Biotechnology
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I-TAC Double Nickase Plasmid (h2) - sc-417548-NIC-2 from Santa Cruz Biotechnology
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I-TAC CRISPR Activation Plasmid (h) - sc-417548-ACT from Santa Cruz Biotechnology
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I-TAC CRISPR Activation Plasmid (h2) - sc-417548-ACT-2 from Santa Cruz Biotechnology
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I-TAC Lentiviral Activation Particles (h) - sc-417548-LAC from Santa Cruz Biotechnology
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I-TAC Lentiviral Activation Particles (h2) - sc-417548-LAC-2 from Santa Cruz Biotechnology
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I-TAC siRNA (h) - sc-45530 from Santa Cruz Biotechnology
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I-TAC shRNA Plasmid (h) - sc-45530-SH from Santa Cruz Biotechnology
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I-TAC shRNA (h) Lentiviral Particles - sc-45530-V from Santa Cruz Biotechnology
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CXCL11/I-TAC RNAi - H00006373-R01 from Novus Biologicals
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MISSION® esiRNA - EHU142501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6798 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6798 from Sigma-Aldrich
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CXCL11 siRNA (Human) - CRH4304 from Cohesion Biosciences
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CXCL11 - MBS8226562 from MyBioSource
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shRNA set against Human CXCL11 (NM_005409.4) - SHH272129 from Creative biogene
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Human CXCL11 siRNA - orb264806 from Biorbyt
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CXCL11 shRNA Plasmid (Human) - CHH4304 from Cohesion Biosciences
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CXCL11 miRNA 3'UTR clone - MiUTR3H-07139 from Creative biogene
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