NFKBIA

Gene Symbol	NFKBIA
Entrez Gene	4792
Alt Symbol	IKBA, MAD-3, NFKBI
Species	Human
Gene Type	protein-coding
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Other Description	I-kappa-B-alpha|IkappaBalpha|NF-kappa-B inhibitor alpha|ikB-alpha|major histocompatibility complex enhancer-binding protein MAD3|nuclear factor of kappa light chain gene enhancer in B-cells
Swissprots	B2R8L6 P25963
Accessions	AAD14949 AAR29599 CAB65110 CAB65111 CAB65112 CAB65113 CAB65114 CAB65556 CAM91165 CBX47574 EAW65875 P25963 AK311515 AK313421 BAG36213 AY033600 AAK51149 BC002601 AAH02601 BC004983 AAH04983 BT007091 AAP35754 BU737609 M69043 AAA16489 NM_020529 NP_065390
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:7479976}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}.
Top Pathways	Legionellosis, Herpes simplex infection, Viral carcinogenesis, Influenza A, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan® Phospho-IκBα (Ser32) Sandwich ELISA Kit - 7355 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-IκBα (Ser32) Sandwich ELISA Antibody Pair - 7343 from Cell Signaling Technology Category Antibody Pair Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan® Total IκBα Sandwich ELISA Kit - 7360 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total IκBα Sandwich ELISA Antibody Pair - 7831 from Cell Signaling Technology Category Antibody Pair Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

SimpleChIP ® Human IκBα Promoter Primers - 5552 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

I kappaB alpha (pS32/36) + Total SimpleStep ELISA™ Kit - ab176661 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests

I kappaB alpha (pS32/36) SimpleStep ELISA™ Kit - ab176643 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity < 0.06 ng/ml Range 0.06 ng/ml - 6 ng/ml

I-kappaBalpha (pS32/36) PhosphoTracer ELISA Kit - ab119631 from Abcam Category ELISA Kit Prices $533.00 Sizes 1 x 96 tests Sensitivity 25 µg/ml Range 25 µg/ml - 2000 µg/ml

I-kappaBalpha Total PhosphoTracer ELISA Kit - ab119630 from Abcam Category ELISA Kit Sensitivity 25 µg/ml Range 25 µg/ml - 2000 µg/ml

IkappaB alpha Total SimpleStep ELISA™ Kit - ab176644 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity < 0.02 ng/ml Range 0.05 ng/ml - 5 ng/ml

IkappaBalpha pSer32/36 + Total PhosphoTracer ELISA Kit - ab119661 from Abcam Category ELISA Kit Sensitivity 25 µg protein/ml Range 25 µg protein/ml - 2000 µg protein/ml

Human NFKBIA / IKB Alpha / IKBA ELISA Kit (Sandwich ELISA) - LS-F5017 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.063 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat NFKBIA / IKB Alpha / IKBA ELISA Kit (Cell-Based ELISA) - LS-F2090 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-NFKBIA / IKB Alpha / IKBA (Tyr305) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1394 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-NFKBIA / IKB Alpha / IKBA (Ser32, Ser36) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1542 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse NFKBIA / IKB Alpha / IKBA ELISA Kit (Sandwich ELISA) - LS-F8758 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Human/Mouse/Rat Phospho-IkB-alpha (S32/S36) Cell-Based ELISA - KCB4809 from R&D Systems Category ELISA Kit Prices $459.00 Sizes 1 kit

Human Total IkB-alpha DuoSet IC ELISA - DYC4299-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 31.20 - 2,000 pg/mL

Human Total IkB-alpha DuoSet IC, 5 Plate - DYC4299-5 from R&D Systems Category ELISA Kit

Human IkBa ELISA Kit - abx151921 from Abbexa Category ELISA Kit Sensitivity 0.055 ng/ml Range 0.156 ng/ml - 10 ng/ml

Inhibitory Subunit of NF Kappa B Alpha, IkBa, Human, ELISA Kit - E-EL-H2407 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Inhibitory Subunit Of NF Kappa B Alpha (IkBa), Human, ELISA Kit - SEB848Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.055ng/mL Range 0.156-10ng/mL

NF-kappa-B inhibitor alpha (NFKBIA), Human, ELISA Kit - CSB-EL015761HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

NF-kappa-B inhibitor alpha (NFKBIA), Human, ELISA Kit - E01N0546 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

NF-kappa-B inhibitor alpha, NFKBIA, Human, ELISA Kit - E1848h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.156-10 ng/mL

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