| Gene Symbol |
Ace
|
| Entrez Gene |
24310
|
| Alt Symbol |
Dcp1, StsRR92
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
angiotensin I converting enzyme
|
| Other Description |
Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)|angiotensin 1 converting enzyme 1|angiotensin I converting enzyme (peptidyl-dipeptidase A) 1|angiotensin I converting enzyme 1|angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)|angiotensin-converting enzyme|dipeptidyl carboxypeptidase I|kininase II
|
| Swissprots |
Q8CFN1 Q7TMC6 P47820 Q9EQM9
|
| Accessions |
AAQ23132 EDM06348 EDM06349 EDM06350 P47820 AF201331 AAG35596 AF201332 AAG35597 AF532783 AAP80808 AF532784 AAP80809 AF539425 AAN17280 AF539701 AAN17281 BC085760 AAH85760 L36664 AAA50505 U03708 AAA82110 U03734 AAA82111 NM_012544 NP_036676
|
| Function |
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Angiotensin-converting enzyme, soluble form: Secreted {ECO:0000250}.
|
| Tissue Specificity |
Testis-specific isoform is expressed in spermatocytes, adult testis. Also expressed in brain, kidney, lung, skeletal muscle and heart. {ECO:0000269|PubMed:12963491}.
|
| Top Pathways |
Hypertrophic cardiomyopathy (HCM), Chagas disease (American trypanosomiasis), Renin-angiotensin system
|