CLU
| Gene Symbol | CLU |
|---|---|
| Entrez Gene | 1191 |
| Alt Symbol | AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | clusterin |
| Other Description | aging-associated protein 4|apolipoprotein J|complement cytolysis inhibitor|complement lysis inhibitor|complement-associated protein SP-40,40|ku70-binding protein 1|sulfated glycoprotein 2|testosterone-repressed prostate message 2 |
| Swissprots | Q2TU75 P11380 P10909 B2R9Q1 Q5HYC1 P11381 B3KSE6 Q7Z5B9 |
| Accessions | AAA60567 AAB06507 AAB25217 AAN78322 AAN87347 AAP88927 CAA01560 CBX53889 CBX53890 P10909 AK093399 BAG52708 AK301324 BAG62873 AK313870 BAG36598 AY513288 AAT08041 BC010514 AAH10514 BC013221 BC019588 AAH19588 BC029972 BF528374 BG819541 BG914262 BM682289 BM723283 BP193735 BQ181025 BQ181739 BX418836 BX459023 BX648414 CAI45990 DN990822 DQ891445 ABM82371 DQ894623 ABM85549 EB385800 J02908 AAA51765 M25915 AAA35692 M26639 AAA36609 M64722 AAB06508 M74816 AAA60321 X14723 CAA32847 XM_006716284 XP_006716347 NM_001831 NP_001822 NR_038335 NR_045494 |
| Function | Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional |
| Subcellular Location | Isoform 1: Secreted. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. |
| Tissue Specificity | Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung. {ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17322305, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:1974459, ECO:0000269|PubMed:2387851, ECO:0000269|PubMed:2780565, ECO:0000269|PubMed:3154963, ECO:0000269|PubMed:8181474, ECO:0000269|PubMed:8292612, ECO:0000269|PubMed:8328966}. |
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