| Gene Symbol |
Asic2
|
| Entrez Gene |
11418
|
| Alt Symbol |
ACIC2, Accn1, BNC1, BNaC1, BNaC1a, Mdeg
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
acid-sensing (proton-gated) ion channel 2
|
| Other Description |
acid-sensing ion channel 2|amiloride-sensitive brain sodium channel|amiloride-sensitive cation channel 1, neuronal (degenerin)|brain sodium channel 1|degenerin
|
| Swissprots |
Q925H0 Q61203 Q5SUU2
|
| Accessions |
EDL15651 Q925H0 AF348465 AAK40101 AK134778 BAE22279 BB342826 BC038551 BC138529 AAI38530 BC138530 AAI38531 CJ282964 EF410081 EF410082 EF410092 EF410096 EF410098 EF410105 EF410106 EF410107 EF410112 EF410114 EF410123 EF410129 EF410130 EF410135 EF410141 EF410143 EF410144 EF410146 EF410147 U57353 AAB49183 Y14634 CAA74978 XM_006531996 XP_006532059 NM_001034013 NP_001029185 NM_007384 NP_031410
|
| Function |
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. {ECO:0000269|PubMed:14762118}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15537887, ECO:0000269|PubMed:15708491}; Multi-pass membrane protein {ECO:0000269|PubMed:15537887, ECO:0000269|PubMed:15708491}. Note=Localized at the plasma membrane, in the soma and punctated peripheral processes of neurons.
|
| Tissue Specificity |
Expressed by sensory neurons. Expressed by nociceptive sensory neurons, spiral ganglion (SG) neurons and the retina (at protein level). Isoform 1 and isoform 2 are expressed in outer nuclear layer of retina (photoreceptors) and to a lower extent in distal and proximal inner nuclear layer. {ECO:0000269|PubMed:14762118, ECO:0000269|PubMed:15537887}.
|
| Top Pathways |
Taste transduction, Inflammatory mediator regulation of TRP channels
|