Gene Symbol | TFPI2 |
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Entrez Gene | 7980 |
Alt Symbol | PP5, REF1, TFPI-2 |
Species | Human |
Gene Type | protein-coding |
Description | tissue factor pathway inhibitor 2 |
Other Description | placental protein 5|retinal pigment epithelium cell factor 1 |
Swissprots | Q66ME8 Q9UC86 Q8NAK6 P48307 |
Accessions | AAK13254 AAK72693 AAS02022 EAL24140 EAW76808 EAW76809 EAW76810 EAW76811 P48307 AK024817 AK075425 AK075427 AK092499 BAC03906 AK129833 AK313260 BAG36070 AY691946 AAU04568 BC005330 AAH05330 BC034155 AAH34155 D29992 BAA06272 DA831865 DA833200 DQ892533 ABM83459 DQ895744 ABM86670 EF488667 ABP02055 L27624 AAA20094 NM_001271003 NP_001257932 NM_001271004 NP_001257933 NM_006528 NP_006519 |
Function | May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. {ECO:0000269|PubMed:7872799}. |
Subcellular Location | Secreted. |
Tissue Specificity | Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. |
TFPI-2 CRISPR/Cas9 KO Plasmid (h) - sc-417987 from Santa Cruz Biotechnology
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TFPI-2 HDR Plasmid (h) - sc-417987-HDR from Santa Cruz Biotechnology
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TFPI-2 Double Nickase Plasmid (h) - sc-417987-NIC from Santa Cruz Biotechnology
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TFPI-2 Double Nickase Plasmid (h2) - sc-417987-NIC-2 from Santa Cruz Biotechnology
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TFPI-2 CRISPR Activation Plasmid (h) - sc-417987-ACT from Santa Cruz Biotechnology
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TFPI-2 CRISPR Activation Plasmid (h2) - sc-417987-ACT-2 from Santa Cruz Biotechnology
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TFPI-2 Lentiviral Activation Particles (h) - sc-417987-LAC from Santa Cruz Biotechnology
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TFPI-2 Lentiviral Activation Particles (h2) - sc-417987-LAC-2 from Santa Cruz Biotechnology
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TFPI-2 siRNA (h) - sc-41062 from Santa Cruz Biotechnology
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TFPI-2 shRNA Plasmid (h) - sc-41062-SH from Santa Cruz Biotechnology
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TFPI-2 shRNA (h) Lentiviral Particles - sc-41062-V from Santa Cruz Biotechnology
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TFPI-2 RNAi - H00007980-R01 from Novus Biologicals
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MISSION® esiRNA - EHU015741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21265 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21265 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03236 from Sigma-Aldrich
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TFPI2 siRNA (Human) - CRH5331 from Cohesion Biosciences
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TFPI2 - MBS8205352 from MyBioSource
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shRNA set against Human TFPI2 (NM_006528.3) - SHH426288 from Creative biogene
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Human TFPI2 siRNA - orb265833 from Biorbyt
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TFPI2 shRNA Plasmid (Human) - CHH5331 from Cohesion Biosciences
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TFPI2 miRNA 3'UTR clone - MiUTR3H-03087 from Creative biogene
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