Gene Symbol | AGTR2 |
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Entrez Gene | 186 |
Alt Symbol | AT2, ATGR2, MRX88 |
Species | Human |
Gene Type | protein-coding |
Description | angiotensin II receptor, type 2 |
Other Description | angiotensin II type-2 receptor|type-2 angiotensin II receptor |
Swissprots | Q6FGY7 Q13016 B2R9V1 P50052 |
Accessions | AAA50762 AAA61794 AAA84900 AAA85851 AAA98990 AAB34100 AAP72969 AAP84355 AAS45437 EAW51502 P50052 AI911273 AK313927 BAG36648 BC095504 AAH95504 CR541969 CAG46767 CR738498 DA538369 U16957 AAA67753 X87723 CAA61022 XM_011537533 XP_011535835 NM_000686 NP_000677 |
Function | Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. {ECO:0000269|PubMed:15123706}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. {ECO:0000269|PubMed:12089445}. |
Top Pathways | Adrenergic signaling in cardiomyocytes, Renin-angiotensin system, Neuroactive ligand-receptor interaction |
AT 2 CRISPR/Cas9 KO Plasmid (h) - sc-418156 from Santa Cruz Biotechnology
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AT 2 HDR Plasmid (h) - sc-418156-HDR from Santa Cruz Biotechnology
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AT 2 Double Nickase Plasmid (h) - sc-418156-NIC from Santa Cruz Biotechnology
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AT 2 Double Nickase Plasmid (h2) - sc-418156-NIC-2 from Santa Cruz Biotechnology
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AT 2 CRISPR Activation Plasmid (h) - sc-418156-ACT from Santa Cruz Biotechnology
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AT 2 CRISPR Activation Plasmid (h2) - sc-418156-ACT-2 from Santa Cruz Biotechnology
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AT 2 Lentiviral Activation Particles (h) - sc-418156-LAC from Santa Cruz Biotechnology
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AT 2 Lentiviral Activation Particles (h2) - sc-418156-LAC-2 from Santa Cruz Biotechnology
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AT 2 siRNA (h) - sc-29752 from Santa Cruz Biotechnology
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AT 2 shRNA Plasmid (h) - sc-29752-SH from Santa Cruz Biotechnology
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AT 2 shRNA (h) Lentiviral Particles - sc-29752-V from Santa Cruz Biotechnology
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AGTR-2 RNAi - H00000186-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1778 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1778 from Sigma-Aldrich
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AGTR2 siRNA (Human) - CRH0131 from Cohesion Biosciences
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AGTR2 - MBS8202555 from MyBioSource
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shRNA set against Human AGTR2 (NM_000686.4) - SHH233530 from Creative biogene
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shRNA set against Human AGTR2(NM_000686.4) - SHG046387 from Creative biogene
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AGTR2 shRNA Plasmid (Human) - CHH0131 from Cohesion Biosciences
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AGTR2 miRNA 3'UTR clone - MiUTR1H-00246 from Creative biogene
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