| Gene Symbol |
ATP13A2
|
| Entrez Gene |
23400
|
| Alt Symbol |
CLN12, HSA9947, KRPPD, PARK9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase type 13A2
|
| Other Description |
probable cation-transporting ATPase 13A2
|
| Swissprots |
Q6S9Z9 Q5JXY2 Q9NQ11 O75700 Q5JXY1
|
| Accessions |
EAW94824 EAW94825 EAW94826 EAW94827 Q9NQ11 AJ009947 CAA08912 AK025928 AK075310 BAC11539 AK290210 BAF82899 AL354615 CAB89728 AL833966 CAD38813 AY461712 AAR23423 AY987009 AAX88804 BC030267 AAH30267 BC034575 AAH34575 HY024349 XM_005245809 XP_005245866 XM_005245810 XP_005245867 XM_005245811 XP_005245868 XM_005245812 XP_005245869 XM_005245813 XP_005245870 XM_005245815 XP_005245872 XM_006710512 XP_006710575 XM_006710513 XP_006710576 XM_011541128 XP_011539430 XM_011541129 XP_011539431 NM_001141973 NP_001135445 NM_001141974 NP_001135446 NM_022089 NP_071372
|
| Function |
May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. {ECO:0000269|PubMed:22186024}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome {ECO:0000269|PubMed:21542062, ECO:0000269|PubMed:22186024}.
|
| Tissue Specificity |
Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons (at protein level). {ECO:0000269|PubMed:22186024}.
|