| Gene Symbol |
Pik3cg
|
| Entrez Gene |
30955
|
| Alt Symbol |
5830428L06Rik, PI3Kgamma, p110gamma
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
phosphoinositide-3-kinase, catalytic, gamma polypeptide
|
| Other Description |
PI3-kinase subunit gamma|PI3K-gamma|p120-PI3K|phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|ptdIns-3-kinase subunit gamma|ptdIns-3-kinase subunit p110-gamma|serine/threonine protein kinase PIK3CG
|
| Swissprots |
Q9JHG7 Q80V09
|
| Accessions |
CAB89851 EDL36893 EDL36894 EDL36895 EDL36896 Q9JHG7 AF208345 AAG41122 AJ249280 CAB89686 AK040543 AK042377 AK052850 AK077772 BAC37000 AK132553 BAE21231 AK137470 BAE23366 AK137620 AK143238 BAE25321 AY831679 AAX76838 BC023250 BC051246 AAH51246 XM_006515112 XP_006515175 XM_006515113 XP_006515176 XR_872416 NM_001146200 NP_001139672 NM_001146201 NP_001139673 NM_020272 NP_064668
|
| Function |
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin- based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}.
|
| Top Pathways |
Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway
|