| Gene Symbol | DPYSL2 |
|---|---|
| Entrez Gene | 1808 |
| Alt Symbol | CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dihydropyrimidinase-like 2 |
| Other Description | collapsin response mediator protein hCRMP-2|dihydropyrimidinase-related protein 2|unc-33-like phosphoprotein 2 |
| Swissprots | Q16555 B4DR31 A8K5H2 D3DSS7 O00424 |
| Accessions | BAA86991 CAR95650 CAT03389 EAW63573 EAW63574 Q16555 AB209195 BAD92432 AB370194 BAF94338 AB370195 BAF94339 AK092377 BAC03872 AK223557 BAD97277 AK291287 BAF83976 AK299077 BAG61143 BC056408 AAH56408 BC067109 AAH67109 BP222303 BX461557 BX463316 BX647115 D78013 BAA11191 DA649686 DC333865 DC344356 U17279 AAA93202 X91250 NM_001197293 NP_001184222 NM_001244604 NP_001231533 NM_001386 NP_001377 |
| Function | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}. Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Axon guidance |