| Gene Symbol |
KRTAP1-5
|
| Entrez Gene |
83895
|
| Alt Symbol |
KAP1.5, KRTAP1.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 1-5
|
| Other Description |
high sulfur keratin-associated protein 1.5|keratin associated protein 1.5|keratin-associated protein 1-5|keratin-associated protein 1.5
|
| Swissprots |
A6NJW6 A6NLZ6 Q52LP6 Q9BYS1 B6ZDR1
|
| Accessions |
EAW60697 Q9BYS1 AJ406928 CAC27567 BC069533 AAH69533 BC093841 AAH93841 BC101555 AAI01556 NM_031957 NP_114163
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
| Tissue Specificity |
Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. {ECO:0000269|PubMed:11279113}.
|