EPHA4

Gene Symbol	EPHA4
Entrez Gene	2043
Alt Symbol	HEK8, SEK, TYRO1
Species	Human
Gene Type	protein-coding
Description	EPH receptor A4
Other Description	EK8|EPH-like kinase 8|TYRO1 protein tyrosine kinase|ephrin type-A receptor 4|receptor protein-tyrosine kinase HEK8|tyrosine-protein kinase TYRO1|tyrosine-protein kinase receptor SEK
Swissprots	B7Z6Q8 A8K2P1 P54764 Q2M380 B2R601
Accessions	AAX81994 AAY24283 AAY24284 CAJ32200 CAT16933 CCQ77687 CCQ77696 CCQ77705 CCQ77714 CDH48193 CDH61615 CDH61669 CDH61688 CDH88986 CDH92524 CDH92538 CDH92549 CDH92796 CDH92893 CDI44668 CDI44677 EAW70785 EAW70786 P54764 AA987900 AF075040 AK225181 AK290306 BAF82995 AK300772 BAH13344 AK312380 BAG35298 AL603465 BC016981 BC026327 AAH26327 BC105000 AAI05001 BC105002 AAI05003 BM676153 BM679073 BM680394 BM712812 BM724253 BQ009361 DA451606 L36645 AAA74246 XM_005246374 XP_005246431 NM_001304536 NP_001291465 NM_001304537 NP_001291466 NM_004438 NP_004429
Function	Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. I
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Early endosome {ECO:0000250}. Note=Clustered upon activation and targeted to early endosome. {ECO:0000250}.
Tissue Specificity	Ubiquitous.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EPHA4 / EPH Receptor A4 ELISA Kit (Sandwich ELISA) - LS-F11379 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 Range 15.6-1000 U/l

Phosphotyrosine EPHA4 / Ephrin Type-A Receptor 4 ELISA Kit - RAB0953 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Ephrin type-A receptor 4, EPHA4, Human, ELISA Kit - E0303h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 U/L

Human Phosphotyrosine EphA4 ELISA - PEL-EPHA4-Y from RayBiotech Category ELISA Kit Prices $390.00, $703.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

EPH receptor A4, ELISA Kit - MBS914925 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human EPHA4is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

Ephrin Type A Receptor 4 (EPHA4), ELISA Kit - MBS2024770 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.114ng/mL. Range 0.313-20ng/mL

ELISA Kit for Ephrin Type A Receptor 4 (EPHA4) - SEE124Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.114ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Ephrin type-A receptor 4(EPHA4) ELISA kit - CSB-EL007724HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml. Range 25 pg/ml-1600 pg/ml

ELISA Kit for Ephrin Type A Receptor 4 (EPHA4) - SEE124Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.114ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse EPHA4 / EPH Receptor A4 ELISA Kit (Custom ELISA) - LS-F14246 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 15.6-1000 U/l

Chicken EPHA4 / EPH Receptor A4 ELISA Kit (Custom ELISA) - LS-F14245 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 15.6-1000 U/l

Human Ephrin type-A receptor 4 ELISA Kit - abx253788 from Abbexa Category ELISA Kit Range 15.6 U/L - 1000 U/L

Human EPHA4 / EPH Receptor A4 ELISA Kit (Sandwich ELISA) - LS-F25447 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 15.6-1000 U/l

Human Ephrin type-A receptor 4 (EPHA4) ELISA Kit - EKC33585 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human Ephrin type-A receptor 4 ELISA Kit - EKE52288 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 10U/L Range 15.6-1000 U/L

EPHA4 - EKH1662 from Nordic BioSite Sensitivity 9.375mIU/ml Range 15.6-1000mIU/ml

EPHA4 ELISA Kit (Human) : 96 Wells (OKEH00372) - OKEH00372 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 10 U/L Range 15.6 - 1,000 U/L

Human Phosphotyrosine EphA4 ELISA - PEL-EPHA4-Y-1 from RayBiotech Category ELISA Kit Prices $398.00, $716.40, $1,592.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human EPHA4 ELISA Kit - E013295 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human EPHA4is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

Human Ephrin type-A receptor 4 ELISA Kit - EK1607 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 10U/L Range 15.6-1000 U/L

anti-EphA4 antibody - ARG55757 from Arigo Biolaboratories Category ELISA Kit

anti-EphA4 antibody - ARG55758 from Arigo Biolaboratories Category ELISA Kit

anti-EphA4 antibody - ARG55774 from Arigo Biolaboratories Category ELISA Kit

Ephrin type-A receptor 4, ELISA Kit - MBS9425468 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 10U/L Range 15.6-1000 U/L

Ephrin type-A receptor 4, ELISA Kit - MBS2886555 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 15.6-1000 U/L

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