| Gene Symbol | EPHA4 |
|---|---|
| Entrez Gene | 2043 |
| Alt Symbol | HEK8, SEK, TYRO1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor A4 |
| Other Description | EK8|EPH-like kinase 8|TYRO1 protein tyrosine kinase|ephrin type-A receptor 4|receptor protein-tyrosine kinase HEK8|tyrosine-protein kinase TYRO1|tyrosine-protein kinase receptor SEK |
| Swissprots | B7Z6Q8 A8K2P1 P54764 Q2M380 B2R601 |
| Accessions | AAX81994 AAY24283 AAY24284 CAJ32200 CAT16933 CCQ77687 CCQ77696 CCQ77705 CCQ77714 CDH48193 CDH61615 CDH61669 CDH61688 CDH88986 CDH92524 CDH92538 CDH92549 CDH92796 CDH92893 CDI44668 CDI44677 EAW70785 EAW70786 P54764 AA987900 AF075040 AK225181 AK290306 BAF82995 AK300772 BAH13344 AK312380 BAG35298 AL603465 BC016981 BC026327 AAH26327 BC105000 AAI05001 BC105002 AAI05003 BM676153 BM679073 BM680394 BM712812 BM724253 BQ009361 DA451606 L36645 AAA74246 XM_005246374 XP_005246431 NM_001304536 NP_001291465 NM_001304537 NP_001291466 NM_004438 NP_004429 |
| Function | Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. I |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Early endosome {ECO:0000250}. Note=Clustered upon activation and targeted to early endosome. {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Axon guidance |