TTN

Gene Symbol TTN
Entrez Gene 7273
Alt Symbol CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD
Species Human
Gene Type protein-coding
Description titin
Other Description connectin|rhabdomyosarcoma antigen MU-RMS-40.14
Swissprots Q7KYN5 Q6PDB1 Q92761 E7EQE6 Q92762 A6NKB1 Q9Y6L9 Q8WZ52 Q7Z2X3 Q7LDM3 Q7KYN4 K7ENY1 Q8TCG8 Q10465 Q15598 E7ET18 Q8WZ42 Q4U1Z6 Q2XUS3 Q9UD97 Q4ZG20 Q6PJP0 Q9UP84 Q8WZ51 Q10466 Q8WZB3 Q32Q60 Q8WZ53 Q6NSG0 Q7KYM2
Accessions AAD22603 AAD22604 AAX88844 ACN81321 CAA45940 CAD12455 CAD12456 CAD12457 CAD12458 CAD12459 CAD12460 EAX11013 EAX11014 EAX11015 EAX11016 EAX11017 EAX11018 EAX11019 Q8WZ42 AF321609 AAT09768 AF525413 AAP80791 AK056602 AK091732 AK092284 BAC03850 AK096883 AK125056 AK129531 AK129919 AL713647 CAD28458 AL832094 AL832351 AL833110 AL833292 BC013396 AAH13396 BC017983 BC026297 BC029400 BC030823 BC058824 AAH58824 BC070170 AAH70170 BC107797 AAI07798 BX537998 CAD97954 DQ248309 ABB55264 EF212153 ABN05229 EF212154 ABN05230 EF212155 ABN05231 EF212156 ABN05232 EU428784 ACA00206 JX424570 AGL91770 X64697 CAA45938 X64698 CAA45939 X69490 CAA49245 X83270 CAA58243 X90568 CAA62188 X90569 CAA62189 X98114 CAA66795 X98115 CAA66796 XM_011511729 XP_011510031 XM_011511730 XP_011510032 XM_011511731 XP_011510033 XM_011511732 XP_011510034 NM_001256850 NP_001243779 NM_001267550 NP_001254479 NM_003319 NP_003310 NM_133378 NP_596869 NM_133379 NP_596870 NM_133432 NP_597676 NM_133437 NP_597681
Function Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:9804419}.
Subcellular Location Cytoplasm {ECO:0000305|PubMed:16410549}. Nucleus {ECO:0000269|PubMed:16410549}.
Tissue Specificity Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level). {ECO:0000269|PubMed:11717165, ECO:0000269|PubMed:7819249}.
Top Pathways Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy

Titin (E-4) - sc-271945 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Titin (E-4): sc-271945. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Titin (E-2) - sc-271946 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dot blot analysis of Titin expression in A-10 (A), SJRH30 (B) and Sol8 (C) whole cell lysates immunoprecipitated with Titin (N-20): sc-8723 and detected with Titin (E-2): sc-271946.

Titin (H-300) - sc-28536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dot blot analysis of Titin expression in A-10 (A), SJRH30 (B) and Sol8 (C) whole cell lysates immunoprecipitated with Titin (H-300): sc-28536 and detected with Titin (E-2): sc-271946.

Titin (C-20) - sc-8724 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Titin (C-20): sc-8724. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing membrane and cytoplasmic staining of myocytes.

Titin (N-20) - sc-8723 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dot blot analysis of Titin expression in A-10 (A), SJRH30 (B) and Sol8 (C) whole cell lysates immunoprecipitated with Titin (N-20): sc-8723 and detected with Titin (E-2): sc-271946.

Titin (G-H5) - sc-100959 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Titin (G-H5): sc-100959. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human skeletal muscle tissue showing nuclear and cytoplasmic localization.

Anti-Titin antibody - ab193218 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded mouse heart tissue labeling Titin with ab193218 at 1/50 dilution.

Anti-Titin antibody [T11] - ab7034 from Abcam

Prices $380.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone T11
ab7034 at 1/100 staining rat soleus muscle tissue sections by IHC-Fr. The tissue was paraformaldehyde fixed and blocked with horse serum. A biotinylated horse anti-mouse IgG was used as the secondary.See Abreview

Anti-TTN / Titin Antibody - LS-C39732 from LifeSpan Bioscience

Prices $495.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal

Anti-TTN / Titin Antibody (clone T11) - LS-C92870 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone T11

Anti-TTN / Titin Antibody - LS-C195250 from LifeSpan Bioscience

Prices $275.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal

Anti-TTN / Titin Antibody - LS-C285743 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TTN / Titin Antibody (aa33779-34025, Biotin) - LS-C300103 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TTN / Titin Antibody (aa33779-34025, FITC) - LS-C304347 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TTN / Titin Antibody (HRP) - LS-C316733 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TTN / Titin Antibody (FITC) - LS-C317095 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TTN / Titin Antibody (Biotin) - LS-C318724 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TTN / Titin Antibody (aa33779-34025) - LS-C296682 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant TTN / Titin.

Anti-TTN / Titin Antibody (clone 7D3) - LS-C133498 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7D3
Immunofluorescence of monoclonal antibody to TTN on HeLa cell. [antibody concentration 10 ug/ml].

Anti-TTN / Titin Antibody (clone 6H5) - LS-C133499 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6H5
Immunofluorescence of monoclonal antibody to TTN on HeLa cell. [antibody concentration 10 ug/ml].

Anti-TTN / Titin Antibody (clone 2B3) - LS-C133497 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B3
Immunoperoxidase of monoclonal antibody to TTN on formalin-fixed paraffin-embedded human skeletal muscle. [antibody concentration 1 ug/ml]

Titin Antibody (T11) - NB600-1206 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone T11

Titin Antibody (6H5) - H00007273-M09 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6H5
Western Blot: Titin Antibody (6H5) [H00007273-M09] - Analysis of TTN expression in transfected 293T cell line by TTN monoclonal antibody (M09), clone 6H5. Lane 1: TTN transfected lysatE (32.8 KDa). Lane 2: Non-transfected lysate.

Titin Antibody (7D3) - H00007273-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7D3
Immunocytochemistry/Immunofluorescence: Titin Antibody (7D3) [H00007273-M06] - Analysis of monoclonal antibody to TTN on HeLa cell. Antibody concentration 10 ug/ml

Titin Antibody (2B3) - H00007273-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B3
Immunocytochemistry/Immunofluorescence: Titin Antibody (2B3) [H00007273-M02] - Analysis of monoclonal antibody to TTN on HeLa cell. Antibody concentration 10 ug/ml.
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