Ago2
| Gene Symbol | Ago2 |
|---|---|
| Entrez Gene | 239528 |
| Alt Symbol | 1110029L17Rik, 2310051F07Rik, AI225898, AL022874, AW546247, ENSMUSG00000072493, Eif2c2, Gerp95, Gm10365, mKIAA4215 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | argonaute RISC catalytic subunit 2 |
| Other Description | Piwi/Argonaute family protein meIF2C2|argonaute 2|argonaute RISC catalytic component 2|eukaryotic translation initiation factor 2C, 2|mAgo2|protein argonaute-2 |
| Swissprots | Q571J6 Q4VAB3 A1A563 Q8CJG0 |
| Accessions | AAN75580 EDL29413 EDL29414 Q8CJG0 AA058301 AA764090 AB081472 BAC15767 AI225898 AI225899 AI415636 AK003962 AK075904 AK142854 BAE25210 AK148725 AK220193 BAD90378 AL022874 AL118169 AW546247 BB765875 BC023279 BC024857 AAH24857 BC056639 AAH56639 BC064741 AAH64741 BC096465 AAH96465 BC128379 AAI28380 BC129922 AAI29923 BE650477 BG072618 BP767325 BY731067 BY732637 CA752432 CJ056675 DQ540998 DQ543695 DQ543696 DQ546154 DQ549215 DQ692047 DQ693350 DQ713527 NM_153178 NP_694818 |
| Function | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t |
| Subcellular Location | Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03031}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03031}. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8. {ECO:0000255|HAMAP-Rule:MF_03031}. |
| Tissue Specificity | Ubiquitous expression in 9.5 day embryos with highest levels in forebrain, heart, limb buds, and branchial arches. {ECO:0000269|PubMed:15284456}. |
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