Gene Symbol | ADRB3 |
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Entrez Gene | 155 |
Alt Symbol | BETA3AR |
Species | Human |
Gene Type | protein-coding |
Description | adrenoceptor beta 3 |
Other Description | adrenergic, beta-3-, receptor|beta-3 adrenergic receptor|beta-3 adrenoceptor|beta-3 adrenoreceptor |
Swissprots | P13945 Q4JFT4 |
Accessions | AAA35550 AAY88743 CAA50142 CAA50143 CAA51383 EAW63343 EAW63344 P13945 AK293033 BAF85722 AK309919 AK313857 BAG36585 AY487247 AAR37414 BC075017 AAH75017 BQ024407 DA904248 FJ170286 ACL14174 FJ170287 ACL14175 S53291 AAB24837 X70811 CAA50141 NM_000025 NP_000016 |
Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed mainly in adipose tissues. |
Top Pathways | Calcium signaling pathway, Endocytosis, Salivary secretion, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction |
β 3 -AR CRISPR/Cas9 KO Plasmid (h) - sc-403301 from Santa Cruz Biotechnology
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β 3 -AR HDR Plasmid (h) - sc-403301-HDR from Santa Cruz Biotechnology
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β 3 -AR Double Nickase Plasmid (h) - sc-403301-NIC from Santa Cruz Biotechnology
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β 3 -AR Double Nickase Plasmid (h2) - sc-403301-NIC-2 from Santa Cruz Biotechnology
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β 3 -AR CRISPR Activation Plasmid (h) - sc-403301-ACT from Santa Cruz Biotechnology
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β 3 -AR CRISPR Activation Plasmid (h2) - sc-403301-ACT-2 from Santa Cruz Biotechnology
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β 3 -AR Lentiviral Activation Particles (h) - sc-403301-LAC from Santa Cruz Biotechnology
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β 3 -AR Lentiviral Activation Particles (h2) - sc-403301-LAC-2 from Santa Cruz Biotechnology
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β 3 -AR siRNA (h) - sc-105010 from Santa Cruz Biotechnology
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β 3 -AR shRNA Plasmid (h) - sc-105010-SH from Santa Cruz Biotechnology
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β 3 -AR shRNA (h) Lentiviral Particles - sc-105010-V from Santa Cruz Biotechnology
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beta-3 Adrenergic R/ADRB3 RNAi - H00000155-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1147 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1147 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1209 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08648 from Sigma-Aldrich
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ADRB3 siRNA (Human) - CRH0109 from Cohesion Biosciences
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ADRB3 - MBS8233102 from MyBioSource
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ADRB3 shRNA Plasmid (Human) - CHH0109 from Cohesion Biosciences
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ADRB3 miRNA 3'UTR clone - MiUTR4H-TG10506 from Creative biogene
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