| Gene Symbol | PI4KB |
|---|---|
| Entrez Gene | 5298 |
| Alt Symbol | NPIK, PI4K-BETA, PI4K92, PI4KBETA, PI4KIIIBETA, PIK4CB |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol 4-kinase, catalytic, beta |
| Other Description | PtdIns 4-kinase beta|phosphatidylinositol 4-kinase beta|phosphatidylinositol 4-kinase, wortmannin-sensitive|type III phosphatidylinositol 4-kinase beta |
| Swissprots | Q5VWB9 P78405 Q9BWR6 B4DGI2 Q9UBF8 Q5VWC0 O15096 Q5VWC1 |
| Accessions | CAC69371 EAW53449 EAW53450 Q9UBF8 AB005910 BAA21661 AJ011121 CAA09495 AK054691 AK294606 BAG57793 AK311292 AL832188 BC000029 AAH00029 BC040300 AAH40300 DC350175 DC365634 U81802 AAC51156 XM_005245264 XP_005245321 XM_011509634 XP_011507936 XM_011509635 XP_011507937 XM_011509636 XP_011507938 XM_011509637 XP_011507939 XM_011509638 XP_011507940 NM_001198773 NP_001185702 NM_001198774 NP_001185703 NM_001198775 NP_001185704 NM_002651 NP_002642 |
| Function | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). {ECO:0000250}. |
| Subcellular Location | Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. |
| Tissue Specificity | Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. {ECO:0000269|PubMed:9020160, ECO:0000269|PubMed:9405935, ECO:0000269|PubMed:9405938}. |
| Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |