| Gene Symbol |
MEIS1
|
| Entrez Gene |
4211
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Meis homeobox 1
|
| Other Description |
Meis1, myeloid ecotropic viral integration site 1 homolog|WUGSC:H_NH0444B04.1|homeobox protein Meis1|leukemogenic homolog protein
|
| Swissprots |
A8MV50 O00470
|
| Accessions |
AAN40012 AAY15006 AAY24268 BAB15814 EAW99892 EAW99893 EAW99894 EAW99895 EAW99896 O00470 AI203963 AK098174 BAG53586 AK297109 BAH12499 AK297817 BAH12671 AK314949 BAG37454 AL832770 BC036511 BC043503 AAH43503 CB854199 U85707 AAC51642 XM_005264321 XP_005264378 XM_005264322 XP_005264379 XM_005264323 XP_005264380 XM_005264324 XP_005264381 XM_005264325 XP_005264382 XR_244932 XR_244933 NM_002398 NP_002389
|
| Function |
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12609849}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|
| Tissue Specificity |
Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer
|